Results 141 to 150 of about 11,865,686 (236)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Editorial: Behavior and Welfare of the Individual Within Large, Commercially-Relevant Groups
Frontiers in Veterinary Science, 2021 Michael J. Toscano +2 more
doaj +1 more source
Algebraic Properties of Curvature Operators in Lorentzian Manifolds with Large Isometry Groups
Symmetry, Integrability and Geometry: Methods and Applications, 2010 Together with spaces of constant sectional curvature and products of a real line with a manifold of constant curvature, the socalled Egorov spaces and ε-spaces exhaust the class of n-dimensional Lorentzian manifolds admitting a group of isometries of ...
Giovanni Calvaruso, Eduardo García-Río
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Corrigendum: Evolutionary emergence of collective intelligence in large groups of students
Frontiers in Psychology, 2023 Santos Orejudo +9 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Characterising large-type Artin groups
We show that the class of large-type Artin groups is invariant under isomorphism, in stark contrast with the corresponding situation for Coxeter groups. We obtain this result by providing a purely algebraic characterisation of large-type Artin groups (i ...
Vaskou, Nicolas +1 more
core +1 more source
The impact of strong feedback on galaxy group scaling relations
Astronomy & AstrophysicsFeedback from active supermassive black holes alters the distribution of matter in the Universe by injecting energy in the neighbouring hot gaseous medium, which leads to ejection of gas from the halos of galaxy groups and massive galaxies.
Eckert D. +18 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source