Results 61 to 70 of about 7,342,884 (290)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Ultrasound diagnostics ofbowel diseases in adults

Pediatria i Medycyna Rodzinna, 2015
Ultrasonography is the first step in the diagnosis of acute and chronic diseases of the abdominal cavity by imaging methods. In an increasing number of cases ultrasound examination is used to diagnose lesions located in the intestines, which beside the 
Andrzej Smereczyński, Katarzyna Kołaczyk   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A PRELIMINARY EUROPEAN LIVER AND INTESTINE TRANSPLANT ASSOCIATION -EUROPEAN LIVER TRANSPLANT REGISTRY STUDY ON INFORMED RECIPIENT CONSENT AND EXTENDED CRITERIA LIVER DONATION

, 2013
The European Liver and Intestine Transplant Association (ELITA) and the European Liver Transplant Registry (ELTR) coordinated the distribution to European liver transplantation centers of an electronic questionnaire, developed by the first author ...
D. Giannarelli, BRUZZONE, Paolo, the European Liver, the European Liver Transplant Registry, Intestine Transplant Association, R. Adam   +5 more
core   +1 more source

P446 The INTESTINE study: INtended TEmporary STomas In crohN's diseasE

, 2023
Background Patients with ileocolic Crohn’s disease may require surgery resulting in temporary stoma formation. The impact on quality of life and morbidity related to stomas is well recognised and timely reversal should be targeted to ...
M Rottoli, the INTESTINE Study Group, Z Garoufalia, G Calini, V Celentano, Alice Gori, S Wexner, C Perrott   +7 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Comparative Assessment of D-Xylose Absorption between Small Intestine and Large Intestine

, 1997
The present study aimed to evaluate the absorption of D-xylose, a passively absorbed five-carbon monosaccharide, from the large intestine compared with the small intestine, in order to explore the absorption potential of the large intestine.
Jun Watanabe, Chiaki Kuno, Hiroaki Yuasa
core   +1 more source

Distinct human stem cell populations in small and large intestine [PDF]

, 2015
The intestine is composed of an epithelial layer containing rapidly proliferating cells that mature into two regions, the small and the large intestine. Although previous studies have identified stem cells as the cell-of-origin for intestinal epithelial ...
Cramer, JM, William LaFramboise, Cramer, Julie M, William LaFramboise (699571), Laframboise, W, Timothy Thompson, Lagasse, E, Albert Geskin (699570), Lagasse, Eric, Julie M Cramer, Eric Lagasse, Thompson, Timothy, LaFramboise, William, Julie M. Cramer (699568), Albert Geskin, Timothy Thompson (699569), Geskin, Albert, Geskin, A, Eric Lagasse (699572), Thompson, T   +19 more
core   +2 more sources