Results 71 to 80 of about 7,342,884 (290)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Structure and function of the large intestine (medical students)

, 2010
This topic begins with a diagrammatic overview of the gastrointestinal (GI) tract with particular relevance to the structure and function of the large intestine. The topic then breaks down into the structure and function of the various parts of the large
Raja Habib, St George's, University of London   +1 more
core  

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Structure and function of the large intestine (nursing students)

, 2010
This topic describes the structure and function of the various parts of the large intestine, including the appendix, caecum, colon (ascending, descending, transverse and sigmoid), rectum and anal canal.
Raja Habib, St George's, University of London   +1 more
core  

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Methodological aspects of large intestine CT in coloproctological patients [PDF]

, 2012
The aim was to study the features of CT scan of large intestine in coloproctological patients. 738 patients with colorectal neoplasm and inflammatory bowel diseases were included in the study and underwent abdominal CT scan and CT colonography ...
A. V. Gorinov, I. V. Zarodnyuk, A. A. Tikhonov   +2 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Clinicodiagnostic value of functional morphological changes of intestine in encephalopathy development in cirrhosis [PDF]

Саратовский научно-медицинский журнал, 2010
The aim of the article is to study frequency and expressiveness of clinico-morphological and dysbiotic intestinal changes in cirrhosis and to estimate its interrelation with manifestations of hepatic encephalopathy. 146 patients with cirrhosis ages 20 to
V.V. Ovsyannikova, I.V. Kozlova
doaj  

Correlation between Thiopurine S-Methyltransferase Genotype and Adverse Events in Inflammatory Bowel Disease Patients

Medicina, 2019
Background and Objectives: In patients with inflammatory bowel diseases (IBD), the use of azathioprine results in adverse events at a rate of 5% to 20%.
Davide Giuseppe Ribaldone, Alessandro Adriani, Gian Paolo Caviglia, Amedeo De Nicolò, Danilo Agnesod, Marco Simiele, Danila Riganò, Rinaldo Pellicano, Roberto Canaparo, Giovanni Di Perri, Antonio D’Avolio, Francesco Luzza, Ludovico Abenavoli, Giorgio Maria Saracco, Marco Astegiano   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source