Results 31 to 40 of about 346,263 (278)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Yantu gongcheng xuebaoRock-socketed piles with large diameter have gradually become the preferred foundation type for large-scale structures under complex geological conditions due to their advantages such as high bearing capacity and low settlement.
XIAO Li 1, 2, DU Fenglei 3, 4, ZHAO Mingrui 1, 2, GAO Wensheng 3, WANG Tao 3, JIANG Hongliang 3
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Applied Sciences, 2020 An analytical model is presented for solving the longitudinal complex impedance of a large-diameter floating pile in viscoelastic surrounding soil with radial heterogeneity and viscous-type damping, taking the effect of three-dimensional wave propagation
Kun Meng +4 more
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Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Experiment on oil and gas explosion of slender pipelines with different length-to-diameter ratios
You-qi chuyun, 2020 To study the law of oil & gas explosion overpressure and flame propagation of slender pipelines with large lengthto-diameter ratios in confined space in oil storage and transportation engineering, an oil and gas explosion experimental system for slender ...
Xinsheng JIANG +5 more
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
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FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
工程科学与技术, 2013 :Pulsed jet can be used to increase gas production,improve the permeability in low permeability gas reservoirs and enhance the yield of wells.According to fluid mechanics, jet mechanics,boundary layer and large-eddy simulation computational theory, the ...
葛兆龙 +4 more
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