Results 81 to 90 of about 2,670,244 (299)

Microstructured cladding elements to enhance performance and flexibility of large mode area leakage channel fibers

Large mode area fibers are imperative for scaling up the average power of fiber lasers. Single-mode behavior and low FM loss are the crucial functionalities for these fibers.
Baskiotis, C., Dasgupta, S., Hayes, J.R., Richardson, D.J.   +3 more
core   +1 more source

Two-dimensional Bragg grating lasers defined by electron-beam lithography [PDF]

, 2006
Two-dimensional Bragg grating (2DBG) lasers with two quarter-wave slip line defects have been designed and fabricated by electron-beam lithography and reactive ion etching.
Choi, John M., DeRose, Guy A., Poon, Joyce K. S., Scherer, Axel, Yariv, Amnon, Zhu, Lin   +5 more
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Anticrossing and Mode Coupling in Bent All-Glass Leakage Channel Microstructured Optical Fibers with Large Mode Area

Photonics
This paper presents the results of a detailed theoretical study of the bending properties of original all-glass leakage channel microstructured optical fibers (LC MOFs) over a bending radius range from 3 cm to 11 cm.
Alexander N. Denisov, Vladislav V. Dvoyrin, Sergey L. Semjonov   +2 more
doaj   +1 more source

Large mode area silicon microstructured fiber with robust dual mode guidance

Optics Express, 2009
A silicon microstructured fiber has been designed and fabricated using a pure silica photonic bandgap guiding fiber as a 3D template for materials deposition. The resulting silicon fiber has a micron sized core but with a small core-cladding index contrast so that it only supports two guided modes.
Healy, N., Sparks, J.R., Petrovich, M.N., Sazio, P.J.A., Badding, J.V., Peacock, A.C.   +5 more
openaire   +4 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A CMOS Spiking Neuron for Brain-Inspired Neural Networks with Resistive Synapses and In-Situ Learning [PDF]

, 2015
Nanoscale resistive memories are expected to fuel dense integration of electronic synapses for large-scale neuromorphic system. To realize such a brain-inspired computing chip, a compact CMOS spiking neuron that performs in-situ learning and computing ...
Balagopal, Sakkarapani, Saxena, Vishal, Wu, Xinyu, Zhu, Kehan   +3 more
core   +3 more sources

Modeling of transverse mode interaction in large-mode-area fiber amplifiers

Optics Express, 2008
We model the transverse mode interaction in a large-mode-area fiber amplifier by solving the Fresnel wave equation including local gain saturation. In order to calculate the electric field distribution we apply a finite difference beam propagation method, which is followed by the derivation of the modal powers and modal polarization states.
N, Andermahr, C, Fallnich
openaire   +2 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source