Results 41 to 50 of about 330,461 (300)

Design and Analysis of a Large Mode Field Area and Low Bending Loss Multi-Cladding Fiber with Comb-Index Core and Gradient-Refractive Index Ring

Sensors, 2023
The large mode field area fiber can raise the tolerance of power, and high requirements for the bending characteristics of optical fibers are needed. In this paper, a fiber composed of a comb-index core, gradient-refractive index ring, and multi-cladding
Yining Zhang, Yudong Lian
doaj   +1 more source

Predicting macrobending loss for large-mode area photonic crystal fibers

, 2004
We report on an easy-to-evaluate expression for the prediction of the bend-loss for a large mode area photonic crystal fiber (PCF) with a triangular air-hole lattice. The expression is based on a recently proposed formulation of the V-parameter for a PCF
Albertsen, M., Bjarklev, A., Bonacinni, D., Folkenberg, J. R., Mortensen, N. A., Nielsen, M. D.   +5 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

High-Order Modes Suppression in All-Glass Large-Mode Area Rare-Earth Doped Optical Fibers with Modified Cladding

Photonics, 2022
In the present work we have developed and realized a high core-to-cladding diameters ratio active optical fibers operated in a single-mode regime due to specially designed structure containing boron-doped and fluorine-doped rods.
Svetlana S. Aleshkina, Maxim M. Khudyakov, Tatiana A. Kashaykina, Mikhail V. Yashkov, Mikhail Yu. Salganskii, Vladimir V. Velmiskin, Mikhail M. Bubnov, Mikhail E. Likhachev   +7 more
doaj   +1 more source

Delamination resistant composites by interleaving bio-based long-chain polyamide nanofibers through optimal control of fiber diameter and fiber morphology [PDF]

, 2020
In this work an innovative electrospinning system is proposed that simultaneously has an adequate temperature resistance, a high increase in mode I (þ51%) and mode II (þ96%) delamination performance and can be commercially produced.
Daelemans, Lode, De Clerck, Karen, Meireman, Timo, Rahier, Hubert, Rijckaert, Sander, Van Paepegem, Wim   +5 more
core   +2 more sources

Extreme large mode area in single-mode pixelated Bragg fiber

Optics Express, 2016
This paper reports the design and the fabrication of an all-solid photonic bandgap fiber with core diameter larger than 100 µm, a record effective mode area of about 3700 µm2 at 1035 nm and robust single-mode behavior on propagation length as short as 90 cm.
Yehouessi, Jean-Paul, Vanvincq, Olivier, Cassez, Andy, Douay, Marc, Quiquempois, Yves, Bouwmans, Géraud, Bigot, Laurent   +6 more
openaire   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Large mode area microstructured fiber supporting 56 super-OAM modes

Optics Express, 2019
In this paper, a kind of super-mode orbital angular momentum microstructured fiber (SM-OAM-MSF) is proposed. By introducing 20 Ge-doped equiangular cylindrical inclusions in the ring-core region, mode coupling mechanism is employed in the formation of super-OAM (SOAM) modes.
Wei, Wang, Hai-Dong, Xu, Qi-Hao, Yang, Fan-Di, Zhou, Zheng-Ran, Li, Ying, Han, Yue-Feng, Qi, Lan-Tian, Hou   +7 more
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source