Results 111 to 120 of about 10,004,845 (289)

Bi-Objective Adaptive Large Neighborhood Search Algorithm for the Healthcare Waste Periodic Location Inventory Routing Problem. [PDF]

Arab J Sci Eng, 2022
Aydemir-Karadag A.
europepmc   +1 more source

Neural Large Neighborhood Search for the Capacitated Vehicle Routing Problem

, 2020
Hottung A, Tierney K. Neural Large Neighborhood Search for the Capacitated Vehicle Routing Problem. In: ECAI 2020.
Hottung, André, Tierney, Kevin ; https://orcid.org/   +1 more
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

An improved large neighborhood search algorithm for solving dynamic pickup and delivery problems

Complex & Intelligent Systems
The large-scale dynamic pickup and delivery problem (DPDP), characterized by a vast number of orders, complex constraints, and the uncertainties introduced by its dynamic nature, poses significant challenges to existing vehicle routing algorithms ...
Qingxia Shang, Yuanji Ming, Minzhong Tan, Bin Qian, Rong Hu, Hao Fang, Liang Feng   +6 more
doaj   +1 more source

Five‐Year Outcomes of Laparoscopic Sphincter‐Preserving Surgery for Rectal Cancer: A Prospective Study in Elderly Vietnamese Patients

Aging and Cancer, EarlyView.
This prospective study demonstrates that laparoscopic sphincter‐preserving surgery is feasible for elderly patients. While overall survival reaches 70% at 5 years, advanced T‐stage and the omission of neoadjuvant therapy significantly drive recurrence, highlighting the need for personalized geriatric protocols despite logistical challenges.
Huu Duc Ho, Quang Le, Ngoc Thach Tran, Van Viet Ung, Loc Vu   +4 more
wiley   +1 more source

A template-based hybrid large neighborhood search for the consistent vehicle routing problem with time-dependent travel times

Journal of Optimization in Industrial Engineering
Customer satisfaction attracts increasing attention in competitive environments. The consistent vehicle routing problem (ConVRP), introduced in recent years, incorporates customer satisfaction into VRP.
Hossein Nikdel, Mohammad Mahdi Nasiri, S. Mohammad J. Mirzapour Al-e-Hashem   +2 more
doaj   +1 more source

A new large neighborhood search based matheuristic framework for rich vehicle routing problems

, 2015
In this paper a New Large Neighborhood Search Based Matheuristic Framework for Rich Vehicle Routing Problems is presented. The innovative aspect of the proposed approach concern the possibility to address large neighborhoods in reasonably small ...
MANCINI, SIMONA, Simona Mancini
core   +1 more source