Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz +3 more
wiley +1 more source
A hybrid adaptive large neighborhood search for time-dependent open electric vehicle routing problem with hybrid energy replenishment strategies. [PDF]
PLoS One, 2023 Fan L.
europepmc +1 more source
Solving Medium to Large Sized Euclidean Generalized Minimum Spanning Tree Problems [PDF]
The generalized minimum spanning tree problem is a generalization of the minimum spanning tree problem. This network design problems finds several practical applications, especially when one considers the design of a large-capacity backbone network ...
Ghosh, Diptesh
core
Multidimensional Profiling of MRI‐Negative Temporal Lobe Epilepsy Uncovers Distinct Phenotypes
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Although hippocampal sclerosis (TLE‐HS) represents the most frequent cause of temporal lobe epilepsy (TLE), up to 30% of patients show no lesion on visual MRI inspection (TLE‐MRIneg). These cases pose diagnostic and therapeutic challenges and are underrepresented in surgical series.
Alice Ballerini +28 more
wiley +1 more source
MathematicsIn this paper, we consider the workflow scheduling problem with soft deadlines and fuzzy time uncertainties in cloud manufacturing environments. Workflow tasks in cloud manufacturing often involve uncertain execution and logistics times due to large ...
Haiyan Xu, Fanhao Ma, Long Chen
doaj +1 more source
Location management for the supply of PD fluid via large neighborhood search based virus optimization algorithm. [PDF]
Sci Rep, 2022 Atthirawong W, Luangpaiboon P.
europepmc +1 more source
Comparison of heuristic approaches for the multiple depot vehicle scheduling problem [PDF]
, 2006 Given a set of timetabled tasks, the multi-depot vehicle scheduling problem is a well-known problem that consists of determining least-cost schedules for vehicles assigned to several depots such that each task is accomplished exactly once by a vehicle ...
Desaulniers, G. (Guy) +3 more
core
Annals of Clinical and Translational Neurology, EarlyView.Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao +6 more
wiley +1 more source
Reinforced Adaptive Large Neighborhood Search
, 2011 The Large Neighborhood Search metaheuristic for solving Constrained Optimization Problems has been proved to be effective on a wide range of problems. This Local Search heuristic has the particu- larity of using a complete search (such as Constraint Programming) to explore the large neighborhoods obtained by relaxing a fragment of the variables of the ...
Mairy, Jean-Baptiste +3 more
openaire +1 more source
Von Economo Neuron Loss in Frontotemporal Dementia: A Meta‐Analysis of Neuropathological Studies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Von Economo neurons (VENs) have been reported to be vulnerable to neurodegeneration in frontotemporal dementia (FTD), particularly the behavioral variant (bvFTD), but these findings have not been systematically assessed across independent brain banks.
Daniel Talmasov +2 more
wiley +1 more source