Results 81 to 90 of about 10,004,845 (289)

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Optimal-Repair Large Neighborhood Search for the Planning of Extensive Fault-Tolerant Distribution Networks

Logistics
Background: Planning power distribution networks is crucial in contemporary infrastructure development. Current distribution paradigms require not only cost minimization but also reliability and fault tolerance.
Renato Bruni, Alberto Geri, Marco Maccioni, Ludovico Nati   +3 more
doaj   +1 more source

Regularized Large Neighborhood Search

Operations research practitioners typically tackle NP-hard combinatorial problems using large neighborhood search (LNS), a scalable heuristic that iteratively refines a current solution by locally re-optimizing subsets of its variables. In contrast, most existing approaches for integrating combinatorial optimization layers into neural networks still ...
Vivier-Ardisson, Germain, Demonet, Laurent, Parmentier, Axel, Blondel, Mathieu   +3 more
openaire   +2 more sources

A survey of very large-scale neighborhood search techniques

Discrete Applied Mathematics, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Department of Industrial, Systems Engineering, University of Florida, P.O. Box 116595, Gainesville, FL 32611, USA ( host institution ), Ahuja, Ravindra K. ( author ), Ergun, Özlem ( author ), Orlin, James B. ( author ), Punnen, Abraham P. ( author )   +5 more
openaire   +2 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Reinforcement Learning-based Large Neighborhood Search Approach to Dock Assignment and Truck Scheduling in Crossdocks

, 2022
International audienceReinforcement Learning-based Large Neighborhood Search Approach to Dock Assignment and Truck Scheduling in ...
Gelareh, Shahin, Neamatian Monemi, Rahimeh, Sanaei, Roozbeh   +2 more
core   +1 more source

Adaptive Large Neighborhood Search for a Production Planning Problem Arising in Pig Farming

Journal of Open Innovation: Technology, Market and Complexity, 2019
. This article aims to resolve a particular production planning and workforce assignment problem. Many production lines may have different production capacities while producing the same product. Each production line is composed of three production stages,
Nat Praseeratasang, Rapeepan Pitakaso, Kanchana Sethanan, Sasitorn Kaewman, Paulina Golinska-Dawson   +4 more
doaj   +1 more source

ANALISA PERBANDINGAN METODE SIMULATED ANNEALING DAN LARGE NEIGHBORHOOD SEARCH UNTUK MEMECAHKAN MASALAH LOKASI DAN RUTE KENDARAAN DUA ESELON

Jurnal Manajemen Industri dan Logistik, 2020
Two-echelon location routing problem (2E-LRP) is a problem that considers distribution problem in a two-level / echelon transport system. The first echelon considers trips from a main depot to a set of selected satellite.
Winarno (Universitas Singaperbangsa Karawang), A. A. N. Perwira Redi (Universitas Pertamina)   +1 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Large neighborhood search for route and fleet optimization in frozen food distribution

OPSI
This study develops an optimization model to enhance the distribution efficiency of a frozen food distributor. The company faces operational inefficiencies due to excessive fleet capacity and conventional route assignment methods, which increase travel ...
Jonathan Andrepa Simbolon, Trismi Ristyowati, Apriani Soepardi, Irwan Soejanto, Yuli dwi Astanti, Puryani, Mochammad Chaeron   +6 more
doaj   +1 more source