Results 91 to 100 of about 452,067 (293)

Immune‐Driven Expression in Inclusion Body Myositis With T‐Cell Large Granular Lymphocytic Leukemia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives T‐cell large granular lymphocytic leukemia (T‐LGLL), reported in up to 58% of inclusion body myositis (IBM) patients, is a rare leukemia of cytotoxic or less commonly helper T cells. The range of myopathies in T‐LGLL and the impact of coexisting T‐LGLL in IBM are not well understood. Our objectives are to investigate the spectrum of
Pannathat Soontrapa, Iago Pinal‐Fernandez, Pritikanta Paul, Michael P. Skolka, Margherita Milone, Min Shi, Mithun V. Shah, Maria Casal‐Dominguez, Katherine Pak, Andrew L. Mammen, Teerin Liewluck   +10 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Low-Complexity Detection/Equalization in Large-Dimension MIMO-ISI Channels Using Graphical Models

, 2011
In this paper, we deal with low-complexity near-optimal detection/equalization in large-dimension multiple-input multiple-output inter-symbol interference (MIMO-ISI) channels using message passing on graphical models.
Chockalingam, A., Datta, Tanumay, Rajan, B. Sundar, Som, Pritam, Srinidhi, N.   +4 more
core   +1 more source

Large Neighborhood Local Search for the Maximum Set Packing Problem [PDF]

, 2013
In this paper we consider the classical maximum set packing problem where set cardinality is upper bounded by $k$. We show how to design a variant of a polynomial-time local search algorithm with performance guarantee $(k+2)/3$. This local search algorithm is a special case of a more general procedure that allows to swap up to $ (\log n)$ elements per
Ward, Justin, Sviridenko, Maxim
openaire   +3 more sources

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

A multiobjective evolutionary algorithm incorporating neighborhood detection for the vehicle routing problem with soft time windows

Complex & Intelligent Systems
The Vehicle Routing Problems with Soft Time Windows (VRPSTWs) presents a common challenge in practical scenarios, which has spurred the development of various algorithmic solutions.
Hao Jiang, Zhiwei Zhang, Chao Wang, Xiaoshu Xiang   +3 more
doaj   +1 more source

Tabu Search for the Single Row Facility Layout Problem in FMS using a 3-opt Neighborhood [PDF]

Since material handling agents in a FMS are most efficient when moving in straight lines, a common layout of machines in a FMS is a single row layout. This allows a floor designer to model the problem of generating an optimal machine layout in a FMS as a
Ghosh, Diptesh, Kothari, Ravi
core  

Adaptive Large Neighborhood Search Enhances Global Network Alignment

VNU Journal of Science: Computer Science and Communication Engineering, 2019
Aligning protein-protein interaction networks from different species is a useful mechanism for figuring out orthologous proteins, predicting/verifying protein unknown functions or constructing evolutionary relationships. The network alignment problem is proved to be NP-hard, requiring exponential-time algorithms, which is not feasible for the fast ...
Do Duc Dong, Dang Thanh Hai, Nguyen Vu Hoang Vuong, Nguyen Trong Dong, Vu Thi Ngoc Anh   +4 more
openaire   +2 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

A Hybrid Solver for Large Neighborhood Search: Mixing Gecode and EasyLocal  + + [PDF]

, 2009
We present a hybrid solver (called $\mathbb{GELATO}$) that exploits the potentiality of a Constraint Programming (CP) environment (Gecode) and of a Local Search (LS) framework (EasyLocal + + ). $\mathbb{GELATO}$ allows to easily develop and use hybrid meta-heuristic combining CP and LS phases (in particular Large Neighborhood Search).
CIPRIANO, Raffaele, DI GASPERO, Luca, DOVIER, Agostino   +2 more
openaire   +2 more sources