Results 91 to 100 of about 9,501,678 (288)

A New Local Search for Continuous Location Problems [PDF]

, 2013
This paper presents a new local search approach for solving continuous location problems. The main idea is to exploit the relation between the continuous model and its discrete counterpart.
Mladenovic, Nenad, Drezner, Zvi, Brimberg, Jack, Salhi, Said   +3 more
core   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Learning a Large Neighborhood Search Algorithm for Mixed Integer Programs [PDF]

, 2022
Large Neighborhood Search (LNS) is a combinatorial optimization heuristic that starts with an assignment of values for the variables to be optimized, and iteratively improves it by searching a large neighborhood around the current assignment.
Sonnerat, Nicolas, Nair, Vinod, Wang, Pengming, Ktena, Ira, Bartunov, Sergey   +4 more
core   +1 more source

N.C.N.C.R. (Newark Commission for Neighborhood Conservation and Rehabilitation)

, 1958
The objective of the Newark Commission for Neighborhood Conservation and Rehabilitation (NCNCR) is better housing for all of the people of Newark through law enforcement, slum clearance, neighborhood conservation, additional housing, rehabilitation and ...

core   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

A multiobjective evolutionary algorithm incorporating neighborhood detection for the vehicle routing problem with soft time windows

Complex & Intelligent Systems
The Vehicle Routing Problems with Soft Time Windows (VRPSTWs) presents a common challenge in practical scenarios, which has spurred the development of various algorithmic solutions.
Hao Jiang, Zhiwei Zhang, Chao Wang, Xiaoshu Xiang   +3 more
doaj   +1 more source

Permutation Flowshop Scheduling in ED Aluminium Using Metaheuristic Approaches

Journal of Industrial Engineering and Halal Industries
This study proposes metaheuristics to solve the permutation flowshop scheduling problem in ED Aluminium which produces kitchen utensils. The aim is to find the processing sequence of products that results in the shortest total completion time, minimizing
Haposan Vincentius Manalu, Fatiha Widyanti, Nur Mayke Eka Normasari, Andiny Trie Oktavia, Achmad Pratama Rifai   +4 more
doaj   +1 more source

Large Neighborhood Local Search for the Maximum Set Packing Problem [PDF]

, 2013
In this paper we consider the classical maximum set packing problem where set cardinality is upper bounded by $k$. We show how to design a variant of a polynomial-time local search algorithm with performance guarantee $(k+2)/3$. This local search algorithm is a special case of a more general procedure that allows to swap up to $Θ(\log n)$ elements per ...
Maxim Sviridenko, Justin Ward
openaire   +4 more sources

Solving Medium to Large Sized Euclidean Generalized Minimum Spanning Tree Problems [PDF]

The generalized minimum spanning tree problem is a generalization of the minimum spanning tree problem. This network design problems finds several practical applications, especially when one considers the design of a large-capacity backbone network ...
Ghosh, Diptesh
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source