Results 71 to 80 of about 10,004,845 (289)

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Very Large-Scale Neighborhood Search for the Quadratic Assignment Problem [PDF]

INFORMS Journal on Computing, 2002
The Quadratic Assignment Problem (QAP) consists of assigning n facilities to n locations so as to minimize the total weighted cost of interactions between facilities. The QAP arises in many diverse settings, is known to be NP-hard, and can be solved to optimality only for fairly small size instances (typically, n is less than or equal to 25 ...
Ahuja, Ravindra, Jha, Krishna, Orlin, James, Sharma, Dushyant   +3 more
openaire   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Large neighborhood search for the bike request scheduling problem

International Transactions in Operational Research, 2019
AbstractThis paper introduces an efficient algorithm for the bike request scheduling problem (BRSP). The BRSP is built around the concept of request, defined as the pickup or dropoff of a number of identical items (bikes) at a specific station, within a certain time window, and with a certain priority.
Nicholas Vergeylen, Kenneth Sörensen, Pieter Vansteenwegen   +2 more
openaire   +5 more sources

A Learning Large Neighborhood Search for the Staff Rerostering Problem

, 2022
To effectively solve challenging staff rerostering problems, we propose to enhance a large neighborhood search (LNS) with a machine learning guided destroy operator. This operator uses a conditional generative model to identify variables that are promising to select and combines this with the use of a special sampling strategy to make the actual ...
Fabio Francisco Oberweger, Günther R. Raidl, Elina Rönnberg, Marc Huber   +3 more
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

An Enhanced Adaptive Large Neighborhood Search for Unrelated Parallel Machine Scheduling With Sequence Dependent Setup Times

, 2023
An Enhanced Adaptive Large Neighborhood Search for Unrelated Parallel Machine Scheduling With Sequence Dependent Setup ...
D Zhang (660807), Samson Yu (13093116), B Ji (7719893), S Zhang (5161223)   +3 more
core   +1 more source

Terrain-Adaptive Global Path Planning Method Based on Bidirectional Variable Neighborhood Search A*

Actuators
To address the issues of low efficiency and non-smooth paths of the A* algorithm in large-scale environments, a terrain-adaptive global path planning method based on Bidirectional Variable Neighborhood Search A* (Terrain-Adaptive Bidirectional Variable ...
Ze Zhang, Ke Liu, Yulong Lei, Yao Fu, Yutong Liu   +4 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Research on the Integrated Scheduling of Imaging and Data Transmission for Earth Observation Satellites

Algorithms
This study focuses on the integrated scheduling issues of imaging and data transmission for Earth observation satellites, where each target needs to be imaged and transmitted within a feasible time window.
Guanfei Yu, Kunlun Zhang
doaj   +1 more source