Results 51 to 60 of about 452,067 (293)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Energies, 2019 This study attempts to optimize the scheduling decision to save production cost (e.g., energy consumption) in a distributed manufacturing environment that comprises multiple distributed factories and where each factory has one flow shop with blocking ...
Xiaohui Zhang +4 more
doaj +1 more source
Asymmetric Arc Routing by Coordinating a Truck and Multiple Drones
Sensors, 2022 Unmanned Aerial Vehicles, commonly known as drones, have been widely used in transmission line inspection and traffic patrolling due to their flexibility and environmental adaptability.
Shuangxi Tian +3 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Multi-Port Stowage Planning for Inland Container Liner Shipping Considering Weight Uncertainties
IEEE Access, 2018 The multi-port stowage planning problem investigates the ship’s whole route to make the stowage plans for multiple ports. This paper formulates the multi-port stowage planning problem for inland container liner shipping on the Yangtze River that ...
Jun Li, Yu Zhang, Jie Ma, Sanyou Ji
doaj +1 more source
International Journal of Aerospace Engineering, 2020 Satellite establishes a satellite ground station to satellite link with a ground station to complete data transmission. However, in China, satellite ground stations only exist within the country.
Yingguo Chen +4 more
doaj +1 more source
A Note on Inhomogeneous Ground States at Large Global Charge [PDF]
, 2017 In this note we search for the ground state, in infinite volume, of the $D=3$ Wilson-Fisher conformal $O(4)$ model, at nonzero values of the two independent charge densities $\rho_{1,2}$.
Hellerman, Simeon +3 more
core +2 more sources
Large Neighborhood Search based on Neural Construction Heuristics
, 2022 We propose a Large Neighborhood Search (LNS) approach utilizing a learned construction heuristic based on neural networks as repair operator to solve the vehicle routing problem with time windows (VRPTW). Our method uses graph neural networks to encode the problem and auto-regressively decodes a solution and is trained with reinforcement learning on ...
Falkner, Jonas K. +2 more
openaire +2 more sources