Results 51 to 60 of about 36,848 (261)

Asymmetric Arc Routing by Coordinating a Truck and Multiple Drones

Sensors, 2022
Unmanned Aerial Vehicles, commonly known as drones, have been widely used in transmission line inspection and traffic patrolling due to their flexibility and environmental adaptability.
Shuangxi Tian, Honghui Chen, Guohua Wu, Jiaqi Cheng   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An Improved Large Neighborhood Search for Network-Level Airport Slot Allocation Optimization

IEEE Access
Airports worldwide face a significant gap between capacity and demand. As a short-term solution, the International Air Transport Association has implemented schedule coordination rules at busy airports.
Qiangzhe Wang, Yuanyuan Ma, Yifan Xu, Zhiyuan Shen, Dan Li   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Adaptive Large Neighborhood Search Metaheuristic for the Capacitated Vehicle Routing Problem with Parcel Lockers

Logistics, 2023
Background: The growth of e-commerce necessitates efficient logistics management to address rising last-mile delivery challenges. To overcome some of the last-mile delivery costs, parcel lockers as a delivery option, can be an alternative solution.
Amira Saker, Amr Eltawil, Islam Ali
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Adaptive Large Neighborhood Search for a Production Planning Problem Arising in Pig Farming

Journal of Open Innovation: Technology, Market and Complexity, 2019
. This article aims to resolve a particular production planning and workforce assignment problem. Many production lines may have different production capacities while producing the same product. Each production line is composed of three production stages,
Nat Praseeratasang, Rapeepan Pitakaso, Kanchana Sethanan, Sasitorn Kaewman, Paulina Golinska-Dawson   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Large neighborhood search for multi-trip vehicle routing [PDF]

European Journal of Operational Research, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
François, Véronique, Arda, Yasemin, Crama, Yves, Laporte, Gilbert   +3 more
openaire   +3 more sources