Results 61 to 70 of about 10,004,845 (289)

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Hydrology-Aware Maintenance Scheduling for a Large Run-of-River Hydropower Plant Using FID-Guided Large Neighborhood Search

Energies
Maintenance scheduling in large run-of-river hydropower plants requires balancing maintenance urgency, asset condition, hydrological opportunity, and operational constraints.
Vinícius Teixeira de Freitas Conceição, Vinícius Ferreira Vidal, Lucas Dias Hudson, João Alisson Mendes Reis, Pedro Paulo Dominguete Carvalho, Leonardo Mello Honório, André Luís Marques Marcato   +6 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

An Adaptive Large Neighborhood Search Algorithm for the Satellite Data Transmission Scheduling Problem

International Journal of Aerospace Engineering, 2020
Satellite establishes a satellite ground station to satellite link with a ground station to complete data transmission. However, in China, satellite ground stations only exist within the country.
Yingguo Chen, Ming Chen, Jun Wen, Yingwu Chen, Wen Xiang   +4 more
doaj   +1 more source

Asymmetric Arc Routing by Coordinating a Truck and Multiple Drones

Sensors, 2022
Unmanned Aerial Vehicles, commonly known as drones, have been widely used in transmission line inspection and traffic patrolling due to their flexibility and environmental adaptability.
Shuangxi Tian, Honghui Chen, Guohua Wu, Jiaqi Cheng   +3 more
doaj   +1 more source

Large neighborhood search for multi-trip vehicle routing [PDF]

European Journal of Operational Research, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
François, Véronique, Arda, Yasemin, Crama, Yves, Laporte, Gilbert   +3 more
openaire   +4 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

An Improved Large Neighborhood Search for Network-Level Airport Slot Allocation Optimization

IEEE Access
Airports worldwide face a significant gap between capacity and demand. As a short-term solution, the International Air Transport Association has implemented schedule coordination rules at busy airports.
Qiangzhe Wang, Yuanyuan Ma, Yifan Xu, Zhiyuan Shen, Dan Li   +4 more
doaj   +1 more source

Multi-Port Stowage Planning for Inland Container Liner Shipping Considering Weight Uncertainties

IEEE Access, 2018
The multi-port stowage planning problem investigates the ship’s whole route to make the stowage plans for multiple ports. This paper formulates the multi-port stowage planning problem for inland container liner shipping on the Yangtze River that ...
Jun Li, Yu Zhang, Jie Ma, Sanyou Ji
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source