Results 61 to 70 of about 452,067 (293)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
An Improved Large Neighborhood Search for Network-Level Airport Slot Allocation Optimization
IEEE AccessAirports worldwide face a significant gap between capacity and demand. As a short-term solution, the International Air Transport Association has implemented schedule coordination rules at busy airports.
Qiangzhe Wang +4 more
doaj +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Logistics, 2023 Background: The growth of e-commerce necessitates efficient logistics management to address rising last-mile delivery challenges. To overcome some of the last-mile delivery costs, parcel lockers as a delivery option, can be an alternative solution.
Amira Saker, Amr Eltawil, Islam Ali
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Parallel Hybrid Trajectory Based Metaheuristics for Real-World Problems [PDF]
, 2015 G. Luque, E. Alba, Parallel Hybrid Trajectory Based Metaheuristics for Real-World Problems, In Proceedings of Intelligent Networking and Collaborative Systems, pp.
Alba-Torres, Enrique +1 more
core +1 more source
Very Large-Scale Neighborhood Search for the Quadratic Assignment Problem [PDF]
SSRN Electronic Journal, 2002 The quadratic assignment problem (QAP) consists of assigning n facilities to n locations to minimize the total weighted cost of interactions between facilities. The QAP arises in many diverse settings, is known to be NP-hard, and can be solved to optimality only for fairly small instances (typically, n ≤ 30).
Ahuja, Ravindra +3 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Adaptive Large Neighborhood Search for a Production Planning Problem Arising in Pig Farming
Journal of Open Innovation: Technology, Market and Complexity, 2019 . This article aims to resolve a particular production planning and workforce assignment problem. Many production lines may have different production capacities while producing the same product. Each production line is composed of three production stages,
Nat Praseeratasang +4 more
doaj +1 more source
A variable neighborhood search simheuristic for project portfolio selection under uncertainty [PDF]
, 2018 With limited nancial resources, decision-makers in rms and governments face the task of selecting the best portfolio of projects to invest in. As the pool of project proposals increases and more realistic constraints are considered, the problem becomes
Döering, Jana +4 more
core +1 more source