Results 41 to 50 of about 36,848 (261)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Energies, 2019 This study attempts to optimize the scheduling decision to save production cost (e.g., energy consumption) in a distributed manufacturing environment that comprises multiple distributed factories and where each factory has one flow shop with blocking ...
Xiaohui Zhang +4 more
doaj +1 more source
Computation, 2021 This research presents a solution to the family tourism route problem by considering daily time windows. To find the best solution for travel routing, the modified adaptive large neighborhood search (MALNS) method, using the four destructions and the ...
Narisara Khamsing +4 more
doaj +1 more source
Learning Large Neighborhood Search Policy for Integer Programming
CoRR, 2021 We propose a deep reinforcement learning (RL) method to learn large neighborhood search (LNS) policy for integer programming (IP). The RL policy is trained as the destroy operator to select a subset of variables at each step, which is reoptimized by an IP solver as the repair operator.
WU, Yaoxin +3 more
openaire +4 more sources
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Multi-Port Stowage Planning for Inland Container Liner Shipping Considering Weight Uncertainties
IEEE Access, 2018 The multi-port stowage planning problem investigates the ship’s whole route to make the stowage plans for multiple ports. This paper formulates the multi-port stowage planning problem for inland container liner shipping on the Yangtze River that ...
Jun Li, Yu Zhang, Jie Ma, Sanyou Ji
doaj +1 more source
International Journal of Aerospace Engineering, 2020 Satellite establishes a satellite ground station to satellite link with a ground station to complete data transmission. However, in China, satellite ground stations only exist within the country.
Yingguo Chen +4 more
doaj +1 more source