Results 101 to 110 of about 1,104,970 (268)

Regularity of large solutions for the compressible magnetohydrodynamic equations

Boundary Value Problems, 2011
In this paper, we consider the initial-boundary value problem of one-dimensional compressible magnetohydrodynamics flows. The existence and continuous dependence of global solutions in H 1 have been established in Chen and Wang (Z Angew Math Phys 54, 608-
Qin Yuming, Peng Xiaozhen, Liu Xin
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Infinitely many large energy solutions of superlinear Schrodinger-Maxwell equations

Electronic Journal of Differential Equations, 2012
In this article we study the existence of infinitely many large energy solutions for the superlinear Schrodinger-Maxwell equations $$displaylines{ -Delta u+V(x)u+ phi u=f(x,u) quad hbox{in }mathbb{R}^3,cr -Delta phi=u^2, quad hbox{in }mathbb{R}^3, }
Lin Li, Shang-Jie Chen
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Large solutions, metasolutions, and asymptotic behaviour of the regular positive solutions of sublinear parabolic problems

Electronic Journal of Differential Equations, 2000
In this paper we analyze the existence of regular and large positive solutions for a class of non-linear elliptic boundary value problems of logistic type in the presence of refuges.
Julian Lopez-Gomez
doaj  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

On the large solutions to a class of k-Hessian problems

Advanced Nonlinear Studies
In this paper, we consider the k-Hessian problem S k(D 2 u) = b(x)f(u) in Ω, u = +∞ on ∂Ω, where Ω is a C ∞-smooth bounded strictly (k − 1)-convex domain in RN ${\mathbb{R}}^{N}$ with N ≥ 2, b ∈ C∞(Ω) is positive in Ω and may be singular or vanish on ∂Ω,
Wan Haitao
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source