Results 41 to 50 of about 28,703 (294)

Delayed Drainage of a Largely Deformed Aquitard due to Abrupt Water Head Decline in Adjacent Aquifer

open access: yesGeofluids, 2018
A governing equation of drawdown was put forward to describe the one-dimensional large-strain consolidation behavior of an aquitard without consideration of the creeping effect. An analytical solution was derived to characterize the drawdown variation in
Zhaofeng Li   +4 more
doaj   +1 more source

A simple permanent deformation model of rockfill materials

open access: yesWater Science and Engineering, 2018
Existing experimental results have shown that using a semi-log linear relationship between the permanent volumetric strain and cyclic number underestimates the volumetric deformation of rockfill materials with a large cyclic number, and that the error ...
De-gao Zou   +4 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Computational Investigations of Large Strain Consolidation and Consolidation-Induced Contaminant Transport / [PDF]

open access: yes, 2014
The phenomenon of coupled consolidation and contaminant transport occurs for a variety of practical applications in the area of geotechnical and geoenvironmental engineering. These applications, among others, include mechanical dewatering of contaminated
Pu, Hefu
core  

An Approach for Description of Elastic Parameters of Cross-Anisotropic Saturated Soils [PDF]

open access: yesEurasian Journal of Science and Engineering, 2018
The processes of deposition and consolidation in natural soils or compaction in fill materials will typically produce soils that are initially cross-anisotropic (also known as transversely isotropic or orthotropic) in terms of both small strain elastic ...
Ahmed Mohammed Hasan
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

One-dimensional large strain thaw consolidation using nonlinear effective stress–void ratio–hydraulic conductivity relationships

open access: yes, 2017
A one-dimensional model for the consolidation of thawing soils is formulated in terms of large strain consolidation and heat transfer equations. The model integrates heat transfer due to conduction, phase change and advection.
Jean-Marie Konrad   +3 more
core   +2 more sources

Evaluating Consolidation Behaviors in High Water Content Oil Sands Tailings Using a Centrifuge

open access: yesGeotechnics
The composition of oil sands tailings is a complex mixture of water, fine clay, sand, silt, and residual bitumen that remains after the extraction of bitumen.
Mahmoud Ahmed   +2 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

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