Results 101 to 110 of about 805,278 (315)

Use of whole-genus genome sequence data to develop a multilocus sequence typing tool that accurately identifies Yersinia isolates to the species and subspecies levels

, 2015
The genus Yersinia is a large and diverse bacterial genus consisting of human-pathogenic species, a fish-pathogenic species, and a large number of environmental species.
Connor, Thomas, Chattaway, Marie A, Chattaway, Marie A., Hall, M, Rajendram, D, Reuter, Sandra, Reuter, S, Rajendram, Dunstan, Savin, C, Connor, Thomas Richard, Jenkins, C, Rajakaruna, L, Van Damme, Inge, Ledeboer, N. A., Van Damme, I, McNally, A, Strauch, Eckhard, Jenkins, Claire, Connor, T, Chattaway, MA, Hall, Miquette, Rajakaruna, Lakshani, Thomson, Nicholas R, Strauch, E, McNally, Alan, Thomson, Nicholas R., Carniel, E, Carniel, Elisabeth, McNally, Alan; id_orcid, Thomson, NR, Savin, Cyril   +30 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

High-throughput generation and comparison of genome-scale metabolic models reveal strain-specific metabolic diversity in 439 Lactococcus strains

mSystems
The emergence of automated methods for the generation of genome-scale metabolic models (GEMs) has enabled the use of these models to study metabolic differences between large sets of different microorganisms.
Jildau Emma Bras, Benjamín J. Sánchez, Nikolaus Sonnenschein, Ahmad A. Zeidan   +3 more
doaj   +1 more source

A DNase encoded by integrated element CJIE1 inhibits natural transformation of Campylobacter jejuni

, 2009
The species Campylobacter jejuni (C. jejuni) is considered naturally competent for DNA uptake and displays strong genetic diversity. Nevertheless, non-naturally transformable strains and several relatively stable clonal lineages exist.
Dep Infectieziekten Immunologie, Graaf-van Bloois, L., van der, Gaasbeek, E.J., Strategic Infection Biology, van Putten, J.P.M., van der Graaf-van Bloois, L., Wagenaar, J.A., Wösten, M.M.S.M., van der Wal, F.J., Wal, F.J., van der, Parker, C.T., Guilhabert, M.R., Putten, J.P.M., van   +12 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Actin and microtubule networks contribute differently to cell response for small and large strains

, 2023
Cytoskeletal filaments provide cells with mechanical stability and organization. The main key players are actin filaments and microtubules governing a cell’s response to mechanical stimuli.
Nnetu, Kenechukwu David, Kubitschke, Hans, Käs, Josef A., Stange, Roland, Schnauß, Jörg, Warmt, Enrico   +5 more
core   +3 more sources

Effect of constitutive law on the erythrocyte membrane response to large strains. [PDF]

Comput Math Appl, 2023
Pepona M, Gounley J, Randles A.
europepmc   +1 more source

Phylo-epidemiological and pathogenic diversity of Mycobacterium tuberculosis strains in London with implications for vaccine develpoment

, 2010
PhDApproximately one-third of the global population is infected with tuberculosis causing approximately 1.7 million deaths. Currently, the BCG vaccine is used to protect against TB, but it cannot prevent primary infection or reactivation of latent ...
Velji, Preya
core  

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source