Results 111 to 120 of about 805,278 (315)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Small variable segments constitute a major type of diversity of bacterial genomes at the species level

, 2010
Analysis of large scale diversity in bacterial genomes has mainly focused on elements such as pathogenicity islands, or more generally, genomic islands. These comprise numerous genes and confer important phenotypes, which are present or absent depending ...
El Karoui, Meriem, Valérie Barbe, Marie-Agnès Petit, Meriem El Karoui, Denamur, Erick, Petit, Marie-Agnès, Fabrice Touzain, Barbe, Valérie, Erick Denamur, Médigue, Claudine, Touzain, Fabrice, Claudine Médigue, Petit, Marie Agnès   +12 more
core   +2 more sources

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

AGAPE (Automated Genome Analysis PipelinE) for Pan-Genome Analysis of Saccharomyces cerevisiae

, 2015
The characterization and public release of genome sequences from thousands of organ- isms is expanding the scope for genetic variation studies. However, understanding the phenotypic consequences of genetic variation remains a challenge in eukaryotes due
Kisurb Choe, Benjamin J. A. Dickins (703565), Stacia Engel (703566), Barbara Dunn, Barbara Dunn (393141), Janos Demeter (5547), Song Giltae, Giltae Song, Dunn Barbara, Jennifer Gallagher, Cherry, JM, Choe, K, Dickins Benjamin J. A., J. Michael Cherry (5627), Demeter, J, Janos Demeter, Dickins, BJA, Snyder, M, Giltae Song (703564), Song, G, Dunn, B, Benjamin J A Dickins, J Michael Cherry, Gallagher, J, Stacia Engel, Engel, S, Demeter Janos, Michael Snyder, Engel Stacia, Cherry J. Michael   +29 more
core   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Differentiation and gene flow among European populations of Leishmania infantum MON-1. [PDF]

, 2008
BACKGROUND: Leishmania infantum is the causative agent of visceral and cutaneous leishmaniasis in the Mediterranean region, South America, and China. MON-1 L.
Schaar, Matthias, Sebastian Ochsenreither, Cañavate Carmen, Haralambous Christos, Mauricio Isabel, Kuhls Katrin, Kuhls, Katrin, Campino, Lenea, Sofia Cortes, Lenea Campino, Francine Pratlong, Pratlong Francine, Soteriadou Ketty, Pratlong, Francine, Haralambous, Christos, Carmen Chicharro, Jean-Pierre Dedet, Schönian Gabriele, Cortes, Sofia, Dedet, Jean-Pierre, Radtke, Oliver A, Cortes Sofia, Soteriadou, Ketty, Ketty Soteriadou, Miles, Michael, Matthias Schaar, Campino Lenea, Carmen Cañavate, Oliver A Radtke, Miles Michael, Isabel Mauricio, Cañavate, Carmen, Katrin Kuhls, Chicharro, Carmen, Chicharro Carmen, Schaar Matthias, Mauricio, Isabel, Christos Haralambous, Ochsenreither Sebastian, Michael Miles, Gabriele Schönian, Ochsenreither, Sebastian, Dedet Jean-Pierre, Radtke Oliver A., Schönian, Gabriele   +44 more
core   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The Measurement of Large Strains With Foil Resistance Strain Gages [PDF]

, 1983
Abstract : Gas factor changes in foil resistance strain gages were observed and measured. Errors due to these changes are discussed and corrections for the gages studied were determined. Residual volume changes during plastic deformation in 7039 Aluminum Alloy and S-7 tool steel were shown to be small and unmeasurable with the gages used.
openaire   +1 more source