Results 91 to 100 of about 805,278 (315)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Oil & Gas Science and Technology, 2006 This paper reviews some aspects of the formulation of the constitutive behavior of a saturated porous material in isothermal evolutions in the domain of large strains. First, the results concerning the nonporous solid are recalled.
Dormieux L., Maghous S.
doaj +1 more source
mBio, 2017 Klebsiella pneumoniae is a major human pathogen responsible for high morbidity and mortality rates. The emergence and spread of strains resistant to multiple antimicrobial agents and documented large nosocomial outbreaks are especially concerning.
S. Wesley Long +8 more
doaj +1 more source
A Large Strains Finite Element Multiscale Approach [PDF]
, 2016 A novel formulation for multiscale finite element analysis of multi-phase solids undergoing large strains is proposed in this paper. Within the described homogenization technique no constitutive assumptions are made at the macrolevel.
Curiel Sosa, J.L., Carneiro Molina, A.J.
core +1 more source
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
BMC Research Notes, 2018 Objective The purpose of this study was to investigate the virulent factors of Vibrio cholerae which caused an unprecedented large cholera outbreak in Ghana in 2014 and progressed into 2015, affected 28,975 people with 243 deaths. Results The V. cholerae
Patrick Kwame Feglo, Miriam Sewurah
doaj +1 more source
Application of the continuum shell finite element SHB8PS to sheet forming simulation using an extended large strain anisotropic elastic–plastic formulation [PDF]
, 2012 http://link.springer.com/article/10.1007%2Fs00419-012-0620-xThis paper proposes an extension of the SHB8PS solid–shell finite element to large strain anisotropic elasto-plasticity, with application to several non-linear benchmark tests including sheet ...
BALAN, Tudor +3 more
core +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Emerging Infectious Diseases, 2008 Tuberculosis patients with identical strains of Mycobacterium tuberculosis are described as clustered. Cluster size may depend on patient or strain characteristics.
Judith R. Glynn +9 more
doaj +1 more source