Results 111 to 120 of about 9,947,482 (276)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Radio-loudness Statistics of Quasars from Quaia-VLASS

The Astrophysical Journal Supplement Series
Quasars are objects of high interest in extragalactic astrophysics, cosmology, and astrometry. One of their useful qualities is their potential radio-loudness.
Nestor Arsenov, Sándor Frey, András Kovács, Lyuba Slavcheva-Mihova   +3 more
doaj   +1 more source

The role of energy shear in the collapse of protohaloes

Astronomy & Astrophysics
Dark matter haloes form from the collapse of matter around special positions in the initial field, those where the local matter flows converge to a point. For such a triaxial collapse to take place, the energy shear tensor (the source of the evolution of
Musso Marcello, Sheth Ravi K.
doaj   +1 more source

Electronic structure of large modified nickel nanoclusters

Condensed Matter Physics, 2006
A combined method of quantum-chemical semiempirical approach MNDO and molecular dynamics with atomic potentials was used while studying the growth of large nanoclusters of nickel.
V.Pokhmurskii, V.Kopylets, S.Kornii
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Galaxy transformation across the cosmic web: The influence zone of filaments

Astronomy & Astrophysics
Context. The matter distribution in the Universe exhibits a rich variety of structures, and they form the so-called cosmic web. These structures arise from the anisotropic gravitational collapse of primordial density fluctuations and define the pathways ...
Alfonso L. Aguerri J., Zarattini Stefano
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Euclid preparation

Astronomy & Astrophysics
We investigated the accuracy and range of validity of the perturbative model for the two-point (2PCF) and three-point (3PCF) correlation functions in real space in view of the forthcoming analysis of the Euclid mission spectroscopic sample.
Guidi M., Veropalumbo A., Pugno A., Moresco M., Sefusatti E., Porciani C., Branchini E., Breton M.-A., Camacho Quevedo B., Crocce M., de la Torre S., Desjacques V., Eggemeier A., Farina A., Kärcher M., Linde D., Marinucci M., Moradinezhad Dizgah A., Moretti C., Pardede K., Pezzotta A., Sarpa E., Amara A., Andreon S., Auricchio N., Baccigalupi C., Bagot D., Baldi M., Bardelli S., Battaglia P., Biviano A., Brescia M., Camera S., Cañas-Herrera G., Capobianco V., Carbone C., Cardone V. F., Carretero J., Castellano M., Castignani G., Cavuoti S., Chambers K. C., Cimatti A., Colodro-Conde C., Congedo G., Conversi L., Copin Y., Courbin F., Courtois H. M., Da Silva A., Degaudenzi H., De Lucia G., Dole H., Douspis M., Dubath F., Dupac X., Dusini S., Escoffier S., Farina M., Farinelli R., Faustini F., Ferriol S., Finelli F., Fosalba P., Fotopoulou S., Frailis M., Franceschi E., Fumana M., Galeotta S., Gillis B., Giocoli C., Gracia-Carpio J., Grazian A., Grupp F., Guzzo L., Haugan S. V. H., Holmes W., Hormuth F., Hornstrup A., Jahnke K., Jhabvala M., Joachimi B., Keihänen E., Kermiche S., Kiessling A., Kubik B., Kümmel M., Kunz M., Kurki-Suonio H., Le Brun A. M. C., Ligori S., Lilje P. B., Lindholm V., Lloro I., Mainetti G., Maino D., Maiorano E., Mansutti O., Marcin S., Marggraf O., Markovic K., Martinelli M., Martinet N., Marulli F., Massey R., Medinaceli E., Mei S., Melchior M., Mellier Y., Meneghetti M., Merlin E., Meylan G., Mora A., Morin B., Moscardini L., Munari E., Neissner C., Niemi S.-M., Padilla C., Paltani S., Pasian F., Pedersen K., Percival W. J., Pettorino V., Pires S., Polenta G., Poncet M., Popa L. A., Raison F., Rebolo R., Renzi A., Rhodes J., Riccio G., Romelli E., Roncarelli M., Saglia R., Sakr Z., Sánchez A. G., Sapone D., Sartoris B., Schewtschenko J. A., Schneider P., Schrabback T., Scodeggio M., Secroun A., Seidel G., Seiffert M., Serrano S., Simon P., Sirignano C., Sirri G., Spurio Mancini A., Stanco L., Steinwagner J., Tallada-Crespí P., Tavagnacco D., Taylor A. N., Tereno I., Tessore N., Toft S., Toledo-Moreo R., Torradeflot F., Tsyganov A., Tutusaus I., Valenziano L., Valiviita J., Vassallo T., Verdoes Kleijn G., Wang Y., Weller J., Zamorani G., Zerbi F. M., Zucca E., Allevato V., Ballardini M., Bolzonella M., Bozzo E., Burigana C., Cabanac R., Calabrese M., Cappi A., Di Ferdinando D., Escartin Vigo J. A., Gabarra L., Martín-Fleitas J., Matthew S., Maturi M., Mauri N., Metcalf R. B., Nucita A. A., Pöntinen M., Risso I., Scottez V., Sereno M., Tenti M., Viel M., Wiesmann M., Akrami Y., Andika I. T., Anselmi S., Archidiacono M., Atrio-Barandela F., Balaguera-Antolinez A., Bertacca D., Bethermin M., Blot L., Böhringer H., Borgani S., Brown M. L., Bruton S., Calabro A., Caro F., Carvalho C. S., Castro T., Cogato F., Conseil S., Contarini S., Cooray A. R., Cucciati O., Davini S., De Paolis F., Desprez G., Díaz-Sánchez A., Diaz J. J., Di Domizio S., Diego J. M., Dimauro P., Enia A., Fang Y., Ferrari A. G., Ferreira P. G., Finoguenov A., Franco A., Ganga K., García-Bellido J., Gasparetto T., Gautard V., Gaztanaga E., Giacomini F., Gianotti F., Gozaliasl G., Gutierrez C. M., Hernández-Monteagudo C., Hildebrandt H., Hjorth J., Joudaki S., Kajava J. J. E., Kang Y., Kansal V., Karagiannis D., Kiiveri K., Kirkpatrick C. C., Kruk S., Lattanzi M., Legrand L., Lembo M., Lepori F., Leroy G., Lesci G. F., Lesgourgues J., Leuzzi L., Liaudat T. I., Loureiro A., Macias-Perez J., Maggio G., Magliocchetti M., Mannucci F., Maoli R., Martins C. J. A. P., Maurin L., Miluzio M., Monaco P., Morgante G., Nadathur S., Naidoo K., Navarro-Alsina A., Nesseris S., Pagano L., Passalacqua F., Paterson K., Patrizii L., Pisani A., Potter D., Quai S., Radovich M., Reimberg P., Rocci P.-F., Rodighiero G., Sacquegna S., Sahlén M., Sanders D. B., Schneider A., Sciotti D., Sellentin E., Smith L. C., Sorce J. G., Tanidis K., Tao C., Testera G., Teyssier R., Tosi S., Troja A., Tucci M., Valieri C., Venhola A., Vergani D., Vernizzi F., Verza G., Vielzeuf P., Walton N. A.   +309 more
doaj   +1 more source