Results 61 to 70 of about 88,250 (260)

Tenecteplase Averting Mechanical Thrombectomy in Emergent Large Vessel Occlusion

The Neurologist, 2019
Introduction: Tenecteplase has recently been studied as an alternative thrombolytic agent in acute stroke, with a possible superior effect in achieving reperfusion of large intracranial vessels. Case Report: A 90-year-old female patient was admitted to our stroke unit because of ...
Psychogios, K., Kargiotis, O., Safouris, A., Magoufis, G., Liakakis, G., Stamboulis, E., Tsivgoulis, G.   +6 more
openaire   +3 more sources

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

FAST-ED scale smartphone app-based prediction of large vessel occlusion in suspected stroke by emergency medical service

Therapeutic Advances in Neurological Disorders, 2021
Background and Purpose: Considering the highly time-dependent therapeutic effect of endovascular treatment in patients with large vessel occlusion–associated acute ischemic stroke, prehospital identification of large vessel occlusion and subsequent ...
Benedikt Frank, Thomas Lembeck, Nina Toppe, Bastian Brune, Bessime Bozkurt, Cornelius Deuschl, Raul G. Nogueira, Marcel Dudda, Joachim Risse, Clemens Kill, Michael Forsting, Christoph Kleinschnitz, Martin Köhrmann   +12 more
doaj   +1 more source

Evaluation of the Dual Impact of Nanotechnologies on Health and Environment Through Alternative Bridging Models

Advanced Healthcare Materials, EarlyView.
This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre, Margherita Bernardeschi, Matteo Battaglini, Gianni Ciofani   +3 more
wiley   +1 more source

Tunable Bioresorbable Scaffolds With Marine Sulfated Polysaccharides for Small‐Caliber Vascular Grafts: A Multi‐Layered Strategy Combining Electrospinning and 4‐Axis Printing

Advanced Healthcare Materials, EarlyView.
A multilayered small‐caliber vascular scaffold combining electrospinning and 4‐axis printing is developed and biofunctionalized with marine sulfated polysaccharides from Holothuria tubulosa. The resulting construct exhibits enhanced hemocompatibility, tunable mechanical properties, and supports endothelial and smooth muscle cell adhesion and ...
Gabriele Obino, Alberto Sensini, Tim ten Brink, Gabriele Nieddu, Tristan Bodet, Giovanni Andrea Deiana, Martijn van Griensven, Marilena Formato, Antonio J. Lepedda, Lorenzo Moroni   +9 more
wiley   +1 more source

Prehospital Scales for Large Vessel Occlusion [PDF]

Stroke, 2017
See related article, p 290 . The strong evidence for benefits of rapid thrombectomy in patients with acute ischemic stroke (AIS) is challenging prehospital systems around the world. Although high-tech endovascular treatment (EVT) works only for a minority of patients, healthcare systems cannot afford to miss suitable candidates anymore. Recent figures
openaire   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Liquid Metal Microrobots for Magnetically Guided Transvascular Navigation

Advanced Materials, EarlyView.
Liquid metal‐based microrobots combine magnetic steering, intrinsic X‐ray visibility and softness, to navigate blood vessels even against flow. Under clinically relevant magnetic fields, liquid metal microrobots roll along vessel walls, cross endothelial barriers, and accumulate in target tissues.
Xiaohui Ju, Roshan Velluvakandy, Xianghua Wu, Miguel Angel Merlos Rodrigo, Zbyněk Heger, Kamila Bendíčková, Jan Frič, Martin Pumera   +7 more
wiley   +1 more source

Blood Biomarkers for Large Vessel Occlusions: A Systematic Review

Stroke: Vascular and Interventional Neurology
BACKGROUND Large vessel occlusions (LVOs), which account for approximately 25% of ischemic strokes, pose a significant challenge due to their severe impact and need for rapid diagnosis and treatment.
Tanaisha Italia, Ilayda Kayir, Ganesh Chilukuri, Saarang Patel, Shray Alpesh Patel, Avi A. Gajjar, Rashad Jabarkheel, Adam Eberle, Oscar A Marcos‐Contreras, Kyle W. Scott, Scott E Kasner, Ruchira M Jha, Bryan Pukenas, Jan‐Karl Burkhardt, Visish M. Srinivasan, Joshua S. Catapano   +15 more
doaj   +1 more source

Advancing the Landscape of RNAi Nanotherapeutics for Ischemic Heart Disease

Advanced Materials, EarlyView.
RNA interference (RNAi) nanomedicine revolutionizes treatment regimens for ischemic heart diseases by enabling tailored, sequence‐anchored gene regulation. This review highlights the recent advances in nanotechnology‐driven RNAi therapeutics for myocardial ischemia and discusses the key design principles that govern efficient delivery, providing ...
Han Gao, Da Pan, Hélder A. Santos
wiley   +1 more source