Large vessel vasculitis - Open Access .click

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Higher Complement C4 Gene Copy Number Constitutes a Shared Genetic Risk Factor for Giant Cell Arteritis and IgA Vasculitis

Arthritis &Rheumatology, EarlyView.
Objective Low copy number (CN) of complement C4 isoforms and high CN of retroviral HERV‐K elements are known risk factors for many immune‐mediated inflammatory diseases (IMIDs), often showing sex‐biased effects. Here, we assessed whether CN variation within the C4 gene contributes to giant cell arteritis (GCA) and IgA vasculitis (IgAV), two complex ...
Laura Martínez‐Gutiérrez +295 more
wiley +1 more source

Unusual manifestations of giant cell arteritis and granulomatosis with polyangiitis

Immunological Medicine, 2019
Giant cell arteritis (GCA) is a type of large vessel vasculitis, and it involves the aorta, large vessels and terminal branches of the external carotid artery, especially the temporal artery.
Ryota Yoshimoto +12 more
doaj +1 more source

Role of imaging in the diagnosis of large and medium-sized vessel vasculitis

, 2013
In large-vessel vasculitis, imaging studies are useful to document temporal artery involvement and crucial to show large-vessel involvement. Color Doppler sonography, magnetic resonance, and computed tomography show early vasculitic lesions.
Hunder, Gene G +3 more
core +1 more source

Age‐Associated B Cells Contribute to Inflammation Via Antibody‐Independent Mechanisms in Takayasu Arteritis

Arthritis &Rheumatology, EarlyView.
Objective Although Takayasu arteritis (TAK) is not a prototypical autoantibody‐mediated disease, accumulating evidence suggests that B cells are involved. This study aimed to investigate the pathway of B cell activation and its contributions to TAK pathogenesis. Methods Histologic analysis of paravascular lymph nodes and affected arteries was conducted
Chenglong Fang +10 more
wiley +1 more source

Multimodality imaging to assess diagnosis and evaluate complications of large vessel arteritis [PDF]

Different types of vasculitis can be distinguished according to the blood vessel's size that is preferentially affected: large-vessel, medium-vessel, and small-vessel vasculitides.
Aghayev, Ayaz +12 more
core +3 more sources

Diagnosis and Assessment of Disease Activity in Takayasu Arteritis: A Childhood Case Illustrating the Challenge

Case Reports in Rheumatology, 2014
Takayasu Arteritis (TA) is a rare, debilitating large vessel vasculitis occurring in patients of all ages, including infants, but the disease most commonly presents in the third decade.
L. Watson +5 more
doaj +1 more source

Aortitis in COVID-19

IDCases, 2021
Corona Virus Disease of 2019 (COVID-19) pandemic has affected more than 67.9 million individuals world-wide and led to more than 15.5 million Deaths. In the initial studies from China, 88.7 % of the patient were noted to have fever, 67 % of the patient ...
Pravash Dhakal +3 more
doaj +1 more source

Management of large-vessel vasculitis

, 2019
PURPOSE OF REVIEW: Glucocorticoids are the mainstay of therapy for large-vessel vasculitis, but potential toxicity and frequent relapses led to studies with nonbiologic and biologic glucocorticoid-sparing agents.
Hatemi, Gulen +3 more
core +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley +1 more source

The Impact of Immunoglobulins on Cardiovascular Diseases and Lipid Profiles in Elderly and Middle‐Aged Chinese Individuals: A 15‐Year Retrospective Study

Journal of Clinical Laboratory Analysis, EarlyView.
In a 15‐year retrospective study of Chinese adults over 45, we explored the links between immunoglobulins, CVDs, and lipid profiles. Temporal increases in IgG and IgA were positively associated with FFAs, offering new insights into humoral immunity and lipid metabolism, suggesting a mechanistic link between humoral immunity and dyslipidemia ...
Ya Li, Li Jiao, Yuan Gao, Xue‐Feng Ni
wiley +1 more source

giant cell arteritis
vasculitis
large-vessel vasculitis

medicine
takayasu arteritis
polyarteritis nodosa