Results 31 to 40 of about 1,972,994 (257)

Factors determining low anterior resection syndrome after rectal cancer resection: A study in Thai patients

Asian Journal of Surgery, 2016
Background/Objective: Defective defecation function, also known as low anterior resection syndrome (LARS), is a common problem after surgical treatment of rectal cancer that has a detrimental effect on quality of life.
Patomphon Ekkarat, Teeranut Boonpipattanapong, Kasaya Tantiphlachiva, Surasak Sangkhathat   +3 more
doaj   +1 more source

Prevalence of low anterior resection syndrome and impact on quality of life after rectal cancer surgery: population‐based study

BJS Open, 2020
Background The prevalence of major low anterior resection syndrome (LARS) after rectal cancer surgery varies from 17·8 to 56·0 per cent, but data from high‐quality studies are sparse.
E. H. A. Pieniowski, C. Nordenvall, G. Palmer, A. Johar, S. Tumlin Ekelund, P. Lagergren, M. Abraham‐Nordling   +6 more
doaj   +1 more source

The efficacy and medium-term outcomes of ligament advanced reinforcement system compared with auto-grafts in anterior cruciate ligament reconstruction: At least 2 years follow-up

Frontiers in Bioengineering and Biotechnology, 2022
Background: Graft choice is an important step in the pre-operative plan of anterior cruciate ligament reconstruction (ACLR). The four-strand hamstring tendon (4SHT) is the most widely used auto-graft, while the Ligament Advanced Reinforcement System ...
Bingxian Ma, Yongxiang Wang, Yongsheng Xu   +2 more
doaj   +1 more source

Prevalence and clinical significance of evacuation disorders in patients with low anterior resection syndrome [PDF]

Annals of Coloproctology
Purpose Low anterior resection syndrome (LARS) manifests with evacuation disorder symptoms and continence problems. However, no prior study has focused on evacuation disorders in patients with LARS.
Yuko Homma, Toshiki Mimura, Koji Koinuma, Hisanaga Horie, Naohiro Sata   +4 more
doaj   +1 more source

Biological and Biomechanical Evaluation of the Ligament Advanced Reinforcement System (LARS AC) in a Sheep Model of Anterior Cruciate Ligament Replacement: A 3-Month and 12-Month Study [PDF]

, 2013
PurposeThe purposes of this study were to assess tissue ingrowth within the Ligament Advanced Reinforcement System (LARS) artificial ligament (LARS AC; LARS, Arc sur Tille, France) and to study the biomechanical characteristics of the reconstructed knees
VIATEAU, Véronique, GUÉRARD, Sandra, Mignonney, Véronique, Manaserro, Mathieu, MITTON, David, MANASSERO, Mathieu, ANAGNOSTOU, Fani, MIGONNEY, Véronique, ANAGOSTOU, Fani   +8 more
core   +1 more source

Can the POLARS tool accurately predict low anterior resection syndrome in rectal cancer patients undergoing laparoscopic resection?

Archives of Medical Science, 2019
Introduction Radical rectal cancer resection can lead to a long-term bowel function impairment known as low anterior resection syndrome (LARS). It remains unclear how to determine which patients are at a higher risk of developing LARS post-surgery.
Paweł Bogacki, Jan Krzak, Tomasz Gach, Wojciech Szwed, Mirosław Szura   +4 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effect of psyllium husk on low anterior resection syndrome after rectal cancer surgery—a pilot prospective cohort study

Frontiers in Surgery
IntroductionLow anterior resection syndrome (LARS) is a frequent, undesired consequence of rectal cancer surgery. Psyllium husk has been suggested as a nutritional supplement in the management of LARS, but without trial-based evidence of its effect.
Silje Stensholt Holte, Silje Stensholt Holte, Natalia Avaliani, Natalia Avaliani, Geir Hoff, Airazat M. Kazaryan, Airazat M. Kazaryan, Airazat M. Kazaryan, Keson Jaioun, Giedrius Lauzikas, Johannes Kurt Schultz, Johannes Kurt Schultz   +11 more
doaj   +1 more source

LARS-like symptoms in the general population may suggest the significance of postoperative functional problems and emotional implications of rectal surgery

Journal of Mind and Medical Sciences, 2019
Background & Aim. Sphincter-saving rectal surgery is prone to cause changes in bowel function associated with Low Anterior Resection Syndrome (LARS). Our aim was to assess LARS-like symptoms within a population of 50-80-year old in order to understand ...
Tudor-Cristian Frunza, Sorinel Lunca, Iustina Baciu, Iulia Axinia, Cezar Valentin Mocanu, Andreea Crudu, Narcis Bujor, Lucia Flavia Livenschi, Claudiu Alexandru Nicolaiev, Andreea Hulubencu, Anca Diaconu, Emilia Valasciu, Ioana Jalobceastai, Malina Tibirna, Mihail Gabriel Dimofte   +14 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source