Results 221 to 230 of about 302,608 (389)

Novel 4,5‐Dihydrothiazole‐Phenylpiperazine Derivatives: Synthesis, Docking Studies and Pharmacological Evaluation as Serotonergic Agents

open access: yesChemMedChem, EarlyView.
The synthesis of a new series of 4,5‐dihydrothiazol‐2‐ylphenylpiperazine derivatives as serotoninergic ligands is described and tested for their affinity toward 5‐HT1A, 5‐HT2A,and 5‐HT2C and selected for further in vivo assays to determine their functional activity. The pharmacological studies highlight that among the developed derivatives, FG‐7 and FG‐
Giorgia Andreozzi   +18 more
wiley   +1 more source

Repurposing Acebutolol for Osteoporosis Treatment: Insights From Multi‐Omics and Multi‐Modal Data Analysis

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Overview of a multi‐omics based drug repurposing strategy. The systematic drug repurposing strategy included the following steps: (1) osteoporosis driver signaling networks were identified from multi‐omics data; (2) drug functional modules were obtained using a network fusion approach to integrate drug similarity information; (3) all drugs were ranked ...
Dan‐Yang Liu   +21 more
wiley   +1 more source

Duração do desenvolvimento e índice de crescimento dos estágios pós embrionários de operárias de Apis mellifera L. (Hymenoptera Apidae)

open access: yesBoletim de Indústria Animal, 2014
Foram analisados a duração do desenvolvimento e o índice de crescimento dos estágio pós-embrionários de operárias de Apis mellifera L., filhas de rainhas africanizadas e italianas.
Maria Santina de Castro Morini   +1 more
doaj  

Microbialite cathodoluminescence: A tool for investigating palaeoredox conditions, alteration histories and primary textures across time

open access: yesThe Depositional Record, EarlyView.
Microbialites are common throughout the rock record and key to our understanding of Earth history, yet a relatively common microscopy technique—cathodoluminescence (CL)—has not previously been leveraged to understand them. In this contribution, we examine microbialites of varying ages (modern to Proterozoic) with CL and report on the patterns and ...
Cedric J. Hagen   +11 more
wiley   +1 more source

Three-dimensionally preserved minute larva of a great-appendage arthropod from the early Cambrian Chengjiang biota

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2016
Yu Liu   +7 more
semanticscholar   +1 more source

Late Pleistocene to Holocene sedimentation in the Great Blue Hole (Lighthouse Reef, Belize): Results from a 30 m long core

open access: yesThe Depositional Record, EarlyView.
A 30 m long sedimentary succession at the bottom of the Belize Blue Hole represents terrestrial cenote (12.5–7.2 ka BP), restricted marine swamp (7.2–5.7 ka BP) and fully marine lagoonal phases (5.7–0 ka BP) on Lighthouse Reef carbonate platform. Post‐glacial and Holocene sea‐level rise largely controlled the sedimentological, faunal and floral changes
Eberhard Gischler   +12 more
wiley   +1 more source

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