Results 1 to 10 of about 3,038 (228)

Revisiting Old Ionophore Lasalocid as a Novel Inhibitor of Multiple Toxins

Toxins, 2020
The ionophore lasalocid is widely used as a veterinary drug against coccidiosis. We found recently that lasalocid protects cells from two unrelated bacterial toxins, the cytotoxic necrotizing factor-1 (CNF1) from Escherichia.
Jean-Christophe Cintrat, Julien Barbier, Emmanuel Lemichez   +2 more
exaly   +5 more sources

Structural Basis of Sequential Enantioselective Epoxidation by a Flavin-Dependent Monooxygenase in Lasalocid A Biosynthesis. [PDF]

Angew Chem Int Ed Engl
Lsd18 is a flavin‐dependent monooxygenase from Streptomyces lasalocidi that performs two enantioselective epoxidations during lasalocid A biosynthesis. X‐ray crystal structures of Lsd18 bound to a substrate and product analogue illuminate how this enzyme performs multiple epoxidations on the same substrate molecule and how it controls stereoselectivity.
Wang Q, Deng Y, Viera D, Liu X, Liu N, Hu Y, Hu X, Wei H, Zhou Q, Lan T, He W, Chen X, Kim CY.   +12 more
europepmc   +4 more sources

Safety and efficacy of a feed additive consisting of lasalocid A sodium (Avatec® 150G) for chickens for fattening and chickens reared for laying (Zoetis Belgium SA) [PDF]

EFSA Journal, 2022
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the coccidiostat lasalocid A sodium (Avatec® 150G) for chickens for fattening and chickens reared for laying.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Fašmon Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Jürgen Gropp, Guido Rychen, Montserrat Anguita, Orsolya Holczknecht, Matteo Lorenzo Innocenti, Alberto Navarro‐Villa, Barbara Rossi, Maria Vittoria Vettori   +25 more
doaj   +3 more sources

Effects of increasing levels of lasalocid supplementation on growth performance, serum biochemistry, ruminal fermentation profile, in vitro nutrient digestibility, and gas production of growing goats [PDF]

Frontiers in Veterinary Science, 2023
IntroductionLasalocid is a feed additive widely used in ruminant nutrition and plays a crucial role in improving livestock productivity, digestibility, immunity, and overall wellbeing.
Saeid M. Basmaeil, Gamaleldin M. Suliman, Maged A. Al Garadi, Mohammed A. Al-Badwi, Mutassim M. Abdelrahman, Fahad S. Al-Harbi, Ahmed M. El-Waziry, Ahmed M. El-Waziry, Ibrahim A. Alhidary, Ayman A. Swelum   +9 more
doaj   +3 more sources

Lasalocid-supplemented diets for improving carcass characteristics, meat quality, and fatty acids content of goats [PDF]

Journal of Animal Science and Technology, 2023
This study investigated the effects of lasalocid supplementation on the diet of goats to improve carcass characteristics, meat quality traits, and fatty acid content. Sixty intact male Ardhi goats were used.
Gamaleldin M. Suliman, Ibrahim A. Alhidary, Ahmed M. El-Waziry, Mutassim M. Abdelrahman, Maged A. Al-Garadi, Abdulkareem M. Matar, Mohammed A. A. Al-Badwi, Fahad S. Al-Harbi, Hussain Al-Sornokh, Saeid M. Basmaeil   +9 more
doaj   +3 more sources

Spectroscopic, Spectrometric and Computational Studies of New Lasalocid Derivatives and Their Complexes with Selected Metal Cations [PDF]

Molecules, 2023
A series of five esters of lasalocid with neopentyl alcohol (LasNeo), geraniol (LasGeran), 2-ethylhexanol (LasEtHex), eicosanol (LasEico) and vanillyl alcohol (LasVanil) were synthesized and studied by NMR, FT-IR and ESI-MS.
Monika Papsdorf, Radosław Pankiewicz
doaj   +2 more sources

Trends in Veterinary Drug Residues in US Cattle: Analysing USDA Sampling Data. [PDF]

Vet Med Sci
National US residue monitoring data (2021–2023) were analysed to characterise veterinary drug residue detections in cattle. Detection patterns varied by cattle type, with dairy cows accounting for the highest number of detections and a consistent group of commonly used drugs responsible for most violative and non‐violative findings.
Alwahaimed AS, Eifert J.
europepmc   +2 more sources

Assessment of the application for modification of the terms of the authorisation of the feed additive consisting of <i>Bacillus velezensis</i>ATCC PTA-6737 (PB6) for all pigs, all poultry species for fattening or reared for laying/breeding, laying hens, minor poultry species for laying and ornamental birds (Kemin Europa N.V.). [PDF]

EFSA J
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the preparation consisting of viable spores of Bacillus velezensis ATCC PTA‐6737 (tradename PB6). PB6 is currently authorised for use as a zootechnical additive (functional group: gut flora stabilisers) for all poultry
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Theodoridou K, Anguita M, Innocenti ML, Galobart J, Brozzi R.   +19 more
europepmc   +2 more sources

Safety and efficacy of a feed additive consisting of <i>Bacillus velezensis</i>NRRL B-67647, <i>Bacillus pumilus</i>NRRL B-67648 and <i>Bacillus licheniformis</i>NRRL B-67649 (Microsaf®) for chickens for fattening, other poultry for fattening and ornamental birds (S.I. Lesaffre). [PDF]

EFSA J
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of Microsaf® when used as a feed additive for chickens for fattening, other poultry for fattening and ornamental birds.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Röhe I, Theodoridou K, Mayo B, Anguita M, Cionci NB, Brozzi R, Innocenti ML, Ortuño J, Valeri P, García-Cazorla Y.   +24 more
europepmc   +2 more sources

Copper(II), a Peculiar Metal Ion for Complexation With Monensin A Ionophore. [PDF]

Chemistry
Copper(II) forms three chiral and EPR‐active complexes with monensinate A in methanol. Beside the bis [CuL2] and mono [CuL]+ species, the new dinuclear construct [Cu2L]3+ exhibits an [ML]+‐type and a metal salt‐type copper(II) centers weakly bound to each other through counter ion(s) and thus, being magnetically independent.
Kis ML, Hajdu B, Jakusch T, Kele Z, Dorkov P, Kukeva R, Pantcheva I, Gyurcsik B.   +7 more
europepmc   +2 more sources