Results 21 to 30 of about 3,038 (228)

P450 Enzyme LyoI Performs Hydro-2,2'-Bifuran Oxidation in the Polyether Ionophore Lysocellin. [PDF]

Angew Chem Int Ed Engl
In a study of the biosynthesis of the polyether ionophore lysocellin, the P450 enzyme LyoI was found to catalyze a rare oxidation of a hydro‐2,2′‐bifuran moiety to its hemiketal form. The oxidation was identified as the key for unlocking the bioactivity of lysocellin.
Rasmussen MH, Møller SLB, Svenningsen EB, Tørring T, Poulsen TB.   +4 more
europepmc   +3 more sources

Structure of a potassium salt of Lasalocid A and an investigation of solid–state conformational variance of the Lasalocid A backbone in known complexes

, 2021
The structure of a potassium salt of the polyether ionophore antibiotic Lasalocid A has been determined by single–crystal X–ray crystallography. A dimeric structure is revealed in which two antibiotic molecules present hemispheric oxygen co–ordination ...
Reeves, Colin R., Hamilton, Darren G., Lynch, Daniel E., Errabelli, Divya R.   +3 more
core   +2 more sources

Safety and efficacy of a feed additive consisting of <i>Bacillus subtilis</i> DSM 32324, <i>Bacillus subtilis</i> DSM 32325 and <i>Bacillus amyloliquefaciens</i> DSM 25840 (GalliPro® Fit & GalliPro® Fit 10) for all poultry (Chr. Hansen A/S). [PDF]

EFSA J
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a feed additive consisting of Bacillus subtilis DSM 32324, B. subtilis DSM 32325 and Bacillus amyloliquefaciens DSM 25840 (GalliPro® Fit 10) as a zootechnical feed additive for all poultry species.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Röhe I, Theodoridou K, Brantom P, Herman L, Anguita M, Galobart J, Innocenti ML, Ortuño J, Brozzi R.   +23 more
europepmc   +2 more sources

Heterocyclic-Fused Squaramides: Anionophores With Antimicrobial Activity. [PDF]

Chembiochem
Supramolecular medicinal chemistry has allowed for the development of novel drugs for the treatment of cystic fibrosis, and in the fight against cancer. However, little has been done to develop these as antimicrobial agents. Here, we describe the development of novel chemical tools to further develop supramolecular methods to combat the global plight ...
Brennan LE, Hawes CS, Kavanagh K, Elmes RBP.   +3 more
europepmc   +2 more sources

Assessment of the feed additive consisting of <i>Enterococcus lactis</i>DSM 10663 NCIMB 10415 (Oralin®) for calves for rearing, piglets, chickens for fattening, turkeys for fattening, cats and dogs for the renewal of its authorisation (Chevita Tierarzneimittel GmbH). [PDF]

EFSA J
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of authorisation of the additive Oralin®, a preparation containing viable cells of Enterococcus lactis DSM 10663 (formerly identified as Enterococcus faecium), as a zootechnical feed additive for ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Theodoridou K, Cocconcelli PS, Mayo B, Anguita M, Bozzi Cionci N, Brozzi R, Innocenti ML, Tarrés-Call J, García-Cazorla Y.   +23 more
europepmc   +2 more sources

Scientific Opinion on the safety and efficacy of Avatec® 150G (lasalocid A sodium) for turkeys

EFSA Journal, 2010
Avatec® 150G is an anticoccidial feed additive containing 15 % lasalocid A sodium, a polyether ionophore produced by fermentation of Streptomyces lasaliensis.
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
doaj   +2 more sources

In vitro comparison of the dermal penetration of three different topical formulations containing lasalocid

Veterinary dermatology (Print), 2017
Background: Topical antimicrobial preparations are of utmost importance in treating suspected and confirmed meticillin-resistant Staphylococcus pseudintermedius (MRSP) infections due to the increasing incidence of widespread resistance to systemic ...
Song, Yunmei, Ebrahimie, Esmaeil, Page, Stephen W., Garg, Sanjay, Knight, Evie C., Zhang, Qian, Mills, Paul C., Shipstone, Michael A., Trott, Darren J.   +8 more
core   +2 more sources

Efficacy of treatments with toltrazuril 7.5% and lasalocid sodium in sheep naturally infected with Eimeria spp.

Revista Brasileira de Parasitologia Veterinária, 2016
The objective of this study was to evaluate the efficacy of an experimental formulation of toltrazuril 7.5% + Trimix™ on a naturally acquired infection of Eimeria spp.
Fernando de Souza Rodrigues, Luiz Eduardo Roland Tavares, Fernando Paiva   +2 more
doaj   +2 more sources

The Effect of Monensin, Lasalocid and a Monensin/Lasalocid Rotation of Fungal Population in the Rumen of Concentrate and Roughage Fed Steers [PDF]

مجلة جامعة النجاح للأبحاث العلوم الطبيعية, 1996
Two studies using three ruminally cannulated beef steers in the first one fed a roughage diet (98% chopped alfalfa at maintenance) and 12 beef steers in the second fed limited ration (85% adlib intake) composed of 90% concentrate diet (80% cracked corn ...
Jamal Abo-Omar
doaj   +2 more sources

Comparative and Functional Analyses Reveal Conserved and Variable Regulatory Systems That Control Lasalocid Biosynthesis in Different <i>Streptomyces</i> Species. [PDF]

Microbiol Spectr, 2023
Compared to its elaborated biosynthetic pathway, the regulation of lasalocid biosynthesis remains obscure. Here, we characterize the roles of regulatory genes in lasalocid biosynthetic gene clusters of two distinct Streptomyces species and identify a ...
Liu M, Wang K, Wei J, Liu N, Niu G, Tan H, Huang Y.   +6 more
europepmc   +2 more sources