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The solution structure of a lasalocid A metal complex in lipophilic solvents
Bioorganic & Medicinal Chemistry, 2005Lasalocid A (LasNa), a common antibiotic in veterinary medicine, is a polyetheral ionophore, disrupting cation equilibria through the cell wall. By means of circular dichroism (in the UV and in the near-IR), paramagnetic NMR, and with the aid of the program PERSEUS, we determined the solution geometry of the 1:1 Las-Yb3+ complex in CD3CN and CDCl3 ...
Ripoli, Silvia +3 more
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Canadian Journal of Animal Science, 1995
Effects of adaptation to L, M or a daily rotation of L and M (R) on in vitro fermentation were measured in a replicated in vitro experiment with a 4 × 4 factorial arrangement of treatments. Treatments were adaptation of ruminal fluid donor steers (0 or 200 mg steer−1 d−1 of L, M or R) and culture ionophore treatment (0 or 4 μg mL−1 of L, M or a 50:50 ...
G. C. Duff, M. L. Galyean, M. E. Branine
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Effects of adaptation to L, M or a daily rotation of L and M (R) on in vitro fermentation were measured in a replicated in vitro experiment with a 4 × 4 factorial arrangement of treatments. Treatments were adaptation of ruminal fluid donor steers (0 or 200 mg steer−1 d−1 of L, M or R) and culture ionophore treatment (0 or 4 μg mL−1 of L, M or a 50:50 ...
G. C. Duff, M. L. Galyean, M. E. Branine
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The Total Synthesis of the Enantiomer of Lasalocid A
1984A convergent total synthesis of the enantiomer of the naturally occurring polyether antibiotic Lasalocid A (X-537A) and preliminary results of the biological testing of this compound are reported.
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A total synthesis of lasalocid A
Journal of the American Chemical Society, 1978T. Nakata +5 more
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Efficacy of Lasalocid against Coccidia in Cattle
The Journal of Parasitology, 1979P R, Fitzgerald, M E, Mansfield
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Neurotoxic action of lasalocid at high doses
Veterinary Record, 1985A, Shlosberg +3 more
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Lasalocid toxicosis is inadequately quantified for horses.
Veterinary and human toxicology, 2002The current estimate of LD50, 21.5 mg/kg BW, for lasalocid in horses is based on an analysis of 8 data from 4 horses that died at dose levels of 15, 21, 22 and 26 mg/kg. This analysis neglected 14 data from another 6 horses that survived at dose levels of 5, 10,14, 18, 19, 25, 29 and 50 mg/kg, and so was biased by selection of data.
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Total synthesis of lasalocid A (X537A)
Journal of the American Chemical Society, 1980Robert E. Ireland +2 more
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