Salinomycin: A new paradigm in cancer therapy [PDF]
Tumor Biology, 2017 The primary hurdle in the treatment of cancer is acquisition of resistance by the tumor cells toward multiple drugs and selectively targeting the cancer stem cells.
Srikanta Kumar Rath +2 more
exaly +4 more sources
High-Resolution Electrospray and Ion Mobility Sequential Mass Spectrometry for Structural Characterisation of Anticancer Stem Cell Agent Salinomycin and Its Isomers [PDF]
MoleculesSalinomycin is a polyether ionophore natural product widely studied for its anticancer stem cell properties and well established anti-coccidial activity.
Candy Jiang, Paul J. Gates
doaj +2 more sources
Chloroquine inhibits salinomycin-induced autophagy for collaborative anticancer effect in breast cancer [PDF]
BioImpactsIntroduction: Breast cancer (BC) presents significant morbidity and mortality challenges. Autophagy plays a contradictory role in BC. The chemotherapeutic agent salinomycin exhibits anticancer effects, but its effectiveness is limited by over-activation ...
Xiaoting Yang +3 more
doaj +2 more sources
In Vitro Antiviral Activities of Salinomycin on Porcine Epidemic Diarrhea Virus
Viruses, 2021 Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus, has catastrophic impacts on the global pig industry. Owing to the lack of effective vaccines and specific therapeutic options for PEDV, it is pertinent to develop new and available ...
, Yichao Ma, Ma Yichao
exaly +3 more sources
The F204S mutation in adrenodoxin oxidoreductase drives salinomycin resistance in Eimeria tenella [PDF]
Veterinary ResearchSalinomycin is a polyether ionophore widely used for the treatment of coccidiosis in poultry. However, the emergence of coccidia strains resistant to salinomycin presents challenges for control efforts, and the mechanisms underlying this resistance in ...
Pei Sun +13 more
doaj +2 more sources
Interplay between autophagy and p38 MAPK during salinomycin-induced cell death in cisplatin-resistant melanoma [PDF]
Scientific ReportsMelanoma, a highly aggressive skin cancer, often develops resistance to chemotherapies like Cisplatin (CDDP), leading to treatment failure. This study investigates the potential of Salinomycin, an antibiotic known for targeting cancer stem cells and ...
Mrityunjay Tyagi, Birija Sankar Patro
doaj +2 more sources
Increased Trypanocidal Activity of the Salinomycin Derivative Ironomycin Is Due to ROS Production and Iron Uptake Impairment [PDF]
MoleculesSalinomycin and its derivatives display promising anti-proliferating activity against bloodstream forms of Trypanosoma brucei. The mechanism of trypanocidal action of these compounds is due to their ionophoretic activity inducing an influx of sodium ...
Dietmar Steverding +6 more
doaj +2 more sources
Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
Medical SciencesCancer is the second leading cause of mortality worldwide. Despite the available treatment options, a majority of cancer patients develop drug resistance, indicating the need for alternative approaches.
Sunny Hunt +2 more
doaj +3 more sources
Multi-Targeting Non-Specific Genome Engineering in Bacteria. [PDF]
Adv Sci (Weinh)In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Sun R +7 more
europepmc +2 more sources
Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens [PDF]
Journal of Veterinary Medical Research, 2009 The present study was conducted to determine the effect of salinomycin at a concentration 60 and 120 ppm alone and with vitamin E or selenium on haematological and biochemical parameters and histopathological changes of the treated chicken.
S.E. El-Sadek +4 more
doaj +3 more sources