Results 1 to 10 of about 389 (88)

Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens [PDF]

Journal of Veterinary Medical Research, 2009
The present study was conducted to determine the effect of salinomycin at a concentration 60 and 120 ppm alone and with vitamin E or selenium on haematological and biochemical parameters and histopathological changes of the treated chicken.
S.E. El-Sadek, M. A. Tohamy, Abeer A. El-Badry, Noha A. M. Fouad, A. A. M. El-Gendy   +4 more
doaj   +3 more sources

Effects of salinomycin and ethanamizuril on the three microbial communities in vivo and in vitro

Frontiers in Microbiology, 2022
The fate of a drug is not only the process of drug metabolism in vivo and in vitro but also the homeostasis of drug-exposed microbial communities may be disturbed.
Xiaolei Cheng, Haihong Zheng, Chunmei Wang, Xiaoyang Wang, Chenzhong Fei, Wen Zhou, Keyu Zhang   +6 more
doaj   +1 more source

Natural and experimental salinomycin poisoning associated with the use of florfenicol in pigs [PDF]

Pesquisa Veterinária Brasileira, 2022
: This study describes the spontaneous and experimental salinomycin poisoning associated with the use of florfenicol and warns about the effects of the administration of antibiotics to animals that receive ionophores in the feed as growth promoters.
Amanda Q. Carvalho, Cláudia S. Wisser, Guilherme O. Manfioletti, Natalia Rigo, José Cristani, Sandra D. Traverso   +5 more
doaj   +1 more source

The comparative assessment of single dose versus co-administration of salinomycin and MK-2206 on viability, apoptosis, and gene expression of human prostate cancer cells

Journal of Current Biomedical Reports, 2023
Globally, the most prevalent medical condition affecting males is identified as prostate cancer (PCa). The aim of the present study was the comparative assessment of single dose versus co-administration of salinomycin and MK-2206 on several laboratory ...
Mohamadreza Savaee, Ali Bakhshi, Mehran Dehghanian, Ghafour Yarahmadi, Fatemeh Yaghoubi, Fatemeh Pourrajab   +5 more
doaj   +1 more source

The Effect of the Supplementation of Humic Substances and Fermented Products in the Feed on the Content of Salinomycin Residues in Poultry Tissues

Foods, 2023
The presence of antimicrobial residues in products of animal origin is a constant problem for consumer health. The aim of this study was to observe the effect of the addition of humic substances (H), fermented products (F) and a mixture of both (FH) to ...
Simona Hriciková, Ivona Kožárová, Beáta Koréneková, Slavomír Marcinčák   +3 more
doaj   +1 more source

Growth, hematological and histopathological responses to guar (cyamopsis tetragonoloba) and salinomycin sodium for ameliorating deleterious effects of coccidiosis in broiler chicken [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021
Coccidiosis is a preeminent threat to productivity in broiler industry. This prospective study was undertaken to evaluate the anti-coccidial efficacy of guar (Cyamopsis tetragonoloba) and Salinomycin Sodium in broiler Chicken.
Omer NASEER, Jawaria Ali KHAN, Muhammad SHAHID, Ameer Hamza RABBANI, Abdullah Saghir AHMAD, Muhammad Luqman SOHAIL, Junaid NASEER, Muhammad BILAL, Waqas ABBAS, Muhammad Usman SALEEM, Yasir Razzaq KHAN, Ahmad ALI, Kashif HUSSAIN   +12 more
doaj   +1 more source

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.

PLoS ONE, 2019
ObjectivesSalinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far.
Johannes Klose, Stefan Trefz, Tobias Wagner, Luca Steffen, Arsalie Preißendörfer Charrier, Praveen Radhakrishnan, Claudia Volz, Thomas Schmidt, Alexis Ulrich, Sebastian M Dieter, Claudia Ball, Hanno Glimm, Martin Schneider   +12 more
doaj   +1 more source

Salinomycin Triggers Human Colorectal Cancer HCT116 Cell Death by Targeting Unfolded Protein Responses and Autophagy Pathways [PDF]

Iranian Journal of Colorectal Research, 2023
Background: Autophagy and the unfolded protein response (UPR) are important pathways in colorectal tumorigenesis and drug resistance, rendering them as potential therapeutic targets for treating this cancer.
Mozhdeh Zamani, Morvarid Siri, Sanaz Dastghaib, Pooneh Mokarram   +3 more
doaj   +1 more source

Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells

Translational Oncology, 2014
Acquiring therapy resistance is one of the major obstacles in the treatment of patients with cancer. The discovery of the cancer stem cell (CSC)–specific drug salinomycin raised hope for improved treatment options by targeting therapy-refractory CSCs and
Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Vijay Kumar Ulaganathan, Annika Herrmann, Nefertiti Elnikhely, Chitra Thakur, Zhiguang Xiao, Pjotr Knyazev, Beyhan Ataseven, Rajkumar Savai, Ernst Wagner, Andreas Roidl   +12 more
doaj   +1 more source

Primary Human Hepatocytes, But not HepG2 or Balb/c 3T3 Cells, Efficiently Metabolize Salinomycin and Are Resistant to Its Cytotoxicity

Molecules, 2020
Salinomycin is a polyether antibiotic showing anticancer activity. There are many reports of its toxicity to animals but little is known about the potential adverse effects in humans. The action of the drug may be connected to its metabolism. That is why
Lidia Radko, Małgorzata Olejnik, Andrzej Posyniak   +2 more
doaj   +1 more source