Results 21 to 30 of about 3,796 (173)

Sequential Salinomycin Treatment Results in Resistance Formation through Clonal Selection of Epithelial-Like Tumor Cells

Translational Oncology, 2014
Acquiring therapy resistance is one of the major obstacles in the treatment of patients with cancer. The discovery of the cancer stem cell (CSC)–specific drug salinomycin raised hope for improved treatment options by targeting therapy-refractory CSCs and
Florian Kopp, Adam Hermawan, Prajakta Shirish Oak, Vijay Kumar Ulaganathan, Annika Herrmann, Nefertiti Elnikhely, Chitra Thakur, Zhiguang Xiao, Pjotr Knyazev, Beyhan Ataseven, Rajkumar Savai, Ernst Wagner, Andreas Roidl   +12 more
doaj   +1 more source

Salinomycin Toxicity in Turkeys

Poultry Science, 1986
Five 7-day trials using 336, 24, 24, 40, and 40 Large White male turkeys when 7, 11, 15, 27, and 32 weeks of age, respectively, were conducted to determine the toxic effects of salinomycin. Salinomycin became more toxic as the age of the turkeys increased.
L M, Potter, J P, Blake, M E, Blair, B A, Bliss, D M, Denbow   +4 more
openaire   +2 more sources

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

BMC Cancer, 2012
Background Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal.
Kuo Selena Z, Blair Katherine J, Rahimy Elham, Kiang Alan, Abhold Eric, Fan Jian-Bing, Wang-Rodriguez Jessica, Altuna Xabier, Ongkeko Weg M   +8 more
doaj   +1 more source

Matrifibrocytes Redefine Cardiac Fibrosis: From Terminal Differentiation to Translational Modulation. [PDF]

J Cell Mol Med
ABSTRACT Cardiac fibrosis is increasingly recognized as a dynamic program that resolves into a terminal fibroblast fate, the matrifibrocyte, rather than a persistent myofibroblast state. Lineage‐tracing and single‐cell studies reveal that matrifibrocytes arise from activated myofibroblasts during late scar maturation, lose α‐SMA and proliferative ...
Zhang Z, Zhu H.
europepmc   +2 more sources

Combinatorial Effect of ARTP Mutagenesis and Ribosome Engineering on an Industrial Strain of Streptomyces albus S12 for Enhanced Biosynthesis of Salinomycin

Frontiers in Bioengineering and Biotechnology, 2019
Salinomycin, an important polyketide, has been widely utilized in agriculture to inhibit growth of pathogenic bacteria. In addition, salinomycin has great potential in treatment of cancer cells.
Kuipu Zhang, Ali Mohsin, Yichen Dai, Zhongbing Chen, Yingping Zhuang, Ju Chu, Meijin Guo   +6 more
doaj   +1 more source

Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species.

PLoS ONE, 2012
BackgroundSalinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance.
Berlinda Verdoodt, Markus Vogt, Inge Schmitz, Sven-Thorsten Liffers, Andrea Tannapfel, Alireza Mirmohammadsadegh   +5 more
doaj   +1 more source

Efficacy of probiotics on health status and growth performance of eimeria tenella infected broiler chickens [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018
A probiotic containing Pediococcus acidilactici and Bacillus subtilis (Smart ProLive) at a 1x107 CFU/mL dose in drinking water were given continuously from the d 14 to the end of the treatment (d 35) in broiler chickens.
S. Zerrin ERDOĞMUŞ, Nurhayat GÜLMEZ, Ayfer FINDIK, Hüseyin ŞAH, Murat GÜLMEZ   +4 more
doaj   +1 more source

In vitro evaluation of salinomycin addition in wheat straw based total mixed diets on rumen fermentation, methanogenesis and dry matter degradability in buffalo

Veterinary World, 2012
Aim: The aim of the current study was to evaluate the effect of salinomycin in vitro on methanogenesis and rumen fermentation. Materials and Methods: Different levels of (0,10, 15 and 20 ppm) salinomycin were checked for their effect on in vitro ...
Sunil K. Sirohi, Navneet Goel
doaj   +1 more source

Salinomycin activates AMP-activated protein kinase-dependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis.

PLoS ONE, 2013
BackgroundThe malignant osteoblastoma has poor prognosis, thus the search for novel and more efficient chemo-agents against this disease is urgent.
Lun-qing Zhu, Yun-fang Zhen, Ya Zhang, Zhi-xiong Guo, Jin Dai, Xiao-dong Wang   +5 more
doaj   +1 more source

Effect of salinomycin on EMT and stemness pathways in 5-FU-resistant breast cancer

Advances in Cancer Biology - Metastasis, 2021
Cancer stem cells (CSCs) present in tumours are the primary cause of cancer recurrence and mediates resistance against therapeutic intervention. CSC properties like epithelial-to-mesenchymal transition (EMT) and cancer stemness lead to metastasis ...
Divya Sivanesan, Raj Pranap Arun, Rama Shanker Verma   +2 more
doaj   +1 more source