Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides
Molecules, 2014 A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods.
Michał Antoszczak +8 more
doaj +2 more sources
Increased Trypanocidal Activity of the Salinomycin Derivative Ironomycin Is Due to ROS Production and Iron Uptake Impairment [PDF]
MoleculesSalinomycin and its derivatives display promising anti-proliferating activity against bloodstream forms of Trypanosoma brucei. The mechanism of trypanocidal action of these compounds is due to their ionophoretic activity inducing an influx of sodium ...
Dietmar Steverding +6 more
doaj +2 more sources
Multi-Targeting Non-Specific Genome Engineering in Bacteria. [PDF]
Adv Sci (Weinh)In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Sun R +7 more
europepmc +2 more sources
Some pharmacodynamic interactions between salinomycin and vitamin E or selenium in chickens [PDF]
Journal of Veterinary Medical Research, 2009 The present study was conducted to determine the effect of salinomycin at a concentration 60 and 120 ppm alone and with vitamin E or selenium on haematological and biochemical parameters and histopathological changes of the treated chicken.
S.E. El-Sadek +4 more
doaj +3 more sources
Natural and experimental salinomycin poisoning associated with the use of florfenicol in pigs [PDF]
Pesquisa Veterinária Brasileira, 2022 : This study describes the spontaneous and experimental salinomycin poisoning associated with the use of florfenicol and warns about the effects of the administration of antibiotics to animals that receive ionophores in the feed as growth promoters.
Amanda Q. Carvalho +5 more
doaj +1 more source
Combined effect of microplastic, salinomycin and heating on Unio tumidus.
Environmental Toxicology and Pharmacology, 2023 Microplastic (MP) and heating (T) suspected to modulate biological effects of aquatic contaminants. Salinomycin (Sal) is veterinary antibiotic and anticancer agent.
V. Martyniuk +6 more
semanticscholar +1 more source
Journal of Current Biomedical Reports, 2023 Globally, the most prevalent medical condition affecting males is identified as prostate cancer (PCa). The aim of the present study was the comparative assessment of single dose versus co-administration of salinomycin and MK-2206 on several laboratory ...
Mohamadreza Savaee +5 more
doaj +1 more source
Cell Death and Disease, 2023 Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs).
Emma Cosialls +17 more
semanticscholar +1 more source
Growth, hematological and histopathological responses to guar (cyamopsis tetragonoloba) and salinomycin sodium for ameliorating deleterious effects of coccidiosis in broiler chicken [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021 Coccidiosis is a preeminent threat to productivity in broiler industry. This prospective study was undertaken to evaluate the anti-coccidial efficacy of guar (Cyamopsis tetragonoloba) and Salinomycin Sodium in broiler Chicken.
Omer NASEER +12 more
doaj +1 more source
Selectivity of cation transport across lipid membranes by the antibiotic salinomycin.
Biochimica et Biophysica Acta - Biomembranes, 2023 The ionophoric antibiotic salinomycin is in the phase of preclinical tests against several types of malignant tumors including breast cancer. Notwithstanding, the data on its ion selectivity, although being critical for its therapeutic activity, are ...
T. Rokitskaya +4 more
semanticscholar +1 more source