Results 21 to 30 of about 5,454 (214)
Salinomycin enhances doxorubicin sensitivity through reversing the epithelial-mesenchymal transition of cholangiocarcinoma cells by regulating ARK5 [PDF]
Brazilian Journal of Medical and Biological Research, 2017 Chemotherapy response rates in patients with cholangiocarcinoma remain low, primarily due to the development of drug resistance. Epithelial-mesenchymal transition (EMT) of cancer cells is widely accepted to be important for metastasis and progression ...
Z. Yu +7 more
doaj +2 more sources
Synthesis, Anticancer and Antibacterial Activity of Salinomycin N-Benzyl Amides
Molecules, 2014 A series of 12 novel monosubstituted N-benzyl amides of salinomycin (SAL) was synthesized for the first time and characterized by NMR and FT-IR spectroscopic methods.
Michał Antoszczak +8 more
doaj +2 more sources
Interplay between autophagy and p38 MAPK during salinomycin-induced cell death in cisplatin-resistant melanoma [PDF]
Scientific ReportsMelanoma, a highly aggressive skin cancer, often develops resistance to chemotherapies like Cisplatin (CDDP), leading to treatment failure. This study investigates the potential of Salinomycin, an antibiotic known for targeting cancer stem cells and ...
Mrityunjay Tyagi, Birija Sankar Patro
doaj +2 more sources
Acute Salinomycin Toxicosis of Pigs [PDF]
Journal of Veterinary Diagnostic Investigation, 1995 Salinomycin is a monovalent carboxylic ionophore that forms lipid-soluble complexes primarily with potassium ions. It was approved as a coccidiostat for chickens by the Federal Drug Administration in 1983. Overdosage or use in nontarget animal species can result in toxicosis. A case of salinomycin toxicosis in pigs is reported here.
K H, Plumlee, B, Johnson, F D, Galey
openaire +2 more sources
Salinomycin as a potential chemotherapeutic compound in cisplatin-resistant ovarian cancer : effects and mechanisms [PDF]
, 2013 Ovarian cancer is the most frequent cause of death from gynecological cancer. Even though there are a lot of options in treating gynecological malignancies, the therapeutic effect of ovarian cancer nowadays is still unfavourable, especially in treatment ...
Bei, Zhang
core +1 more source
Salinomycin Toxicity in Turkeys
Poultry Science, 1986 Five 7-day trials using 336, 24, 24, 40, and 40 Large White male turkeys when 7, 11, 15, 27, and 32 weeks of age, respectively, were conducted to determine the toxic effects of salinomycin. Salinomycin became more toxic as the age of the turkeys increased.
L M, Potter +4 more
openaire +2 more sources
BMC Cancer, 2012 Background Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal.
Kuo Selena Z +8 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2019 Salinomycin, an important polyketide, has been widely utilized in agriculture to inhibit growth of pathogenic bacteria. In addition, salinomycin has great potential in treatment of cancer cells.
Kuipu Zhang +6 more
doaj +1 more source
In Vitro Antiviral Activities of Salinomycin on Porcine Epidemic Diarrhea Virus
Viruses, 2021 Porcine epidemic diarrhea virus (PEDV), an enteropathogenic coronavirus, has catastrophic impacts on the global pig industry. Owing to the lack of effective vaccines and specific therapeutic options for PEDV, it is pertinent to develop new and available ...
Chen Yuan +6 more
doaj +1 more source
PLoS ONE, 2012 BackgroundSalinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance.
Berlinda Verdoodt +5 more
doaj +1 more source