Results 11 to 20 of about 7,383 (256)
Salinomycin: A new paradigm in cancer therapy [PDF]
Tumor Biology, 2017 The primary hurdle in the treatment of cancer is acquisition of resistance by the tumor cells toward multiple drugs and selectively targeting the cancer stem cells.
Jayant Dewangan +2 more
doaj +4 more sources
Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer
Medical SciencesCancer is the second leading cause of mortality worldwide. Despite the available treatment options, a majority of cancer patients develop drug resistance, indicating the need for alternative approaches.
Sunny Hunt +2 more
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Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.
PLoS ONE, 2019 ObjectivesSalinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far.
Johannes Klose +12 more
doaj +2 more sources
Retrospective Study of Salinomycin Toxicosis in 66 Cats [PDF]
Veterinary Medicine International, 2010 We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes.
Pakozdy, Akos +6 more
openaire +6 more sources
Monitoring of autophagy is complicated—salinomycin as an example
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015 Monitoring of autophagy is challenging because of its multiple steps and lack of single befitting technique for a complete mechanistic understanding, which makes the task complicated. Here, we evaluate the functionality of autophagy triggered by salinomycin (anti-cancer stem cell agent) using flow cytometry and advanced microscopy.
Jangamreddy, Jaganmohan Reddy +2 more
openaire +3 more sources
Impact of salinomycin on the intestinal microflora of broiler chickens [PDF]
Acta Veterinaria Scandinavica, 2007 Background The ionophoric coccidiostat salinomycin is widely used in chicken feed. In the near future the use of ionophore coccidiostats may be banned as has been the case for other antimicrobial growth promoters.
Pedersen Karl +2 more
doaj +2 more sources
Translational Oncology, 2014 Acquiring therapy resistance is one of the major obstacles in the treatment of patients with cancer. The discovery of the cancer stem cell (CSC)–specific drug salinomycin raised hope for improved treatment options by targeting therapy-refractory CSCs and
Florian Kopp +12 more
doaj +3 more sources
Interplay between autophagy and p38 MAPK during salinomycin-induced cell death in cisplatin-resistant melanoma [PDF]
Scientific ReportsMelanoma, a highly aggressive skin cancer, often develops resistance to chemotherapies like Cisplatin (CDDP), leading to treatment failure. This study investigates the potential of Salinomycin, an antibiotic known for targeting cancer stem cells and ...
Mrityunjay Tyagi, Birija Sankar Patro
doaj +2 more sources
PATHOLOGICAL AND SERUM BIOCHEMICAL EFFECTS OF SALINOMYCIN ON LAYER CHICKS [PDF]
Pakistan Veterinary Journal, 2008 Effects of continuous and over dosage of salinomycin was studied experimentally in layer chicks.Salinomycin was given to layers @ 60, 120 and 180 ppm in feed up to the age of 12 weeks.
F. RIZVI, A. D. ANJUM, A. KHAN, M. MOHSAN AND M. SHAZAD
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Salinomycin enhances doxorubicin sensitivity through reversing the epithelial-mesenchymal transition of cholangiocarcinoma cells by regulating ARK5 [PDF]
Brazilian Journal of Medical and Biological Research, 2017 Chemotherapy response rates in patients with cholangiocarcinoma remain low, primarily due to the development of drug resistance. Epithelial-mesenchymal transition (EMT) of cancer cells is widely accepted to be important for metastasis and progression ...
Z. Yu +7 more
doaj +2 more sources