Results 11 to 20 of about 3,796 (173)

Effects of salinomycin and ethanamizuril on the three microbial communities in vivo and in vitro

Frontiers in Microbiology, 2022
The fate of a drug is not only the process of drug metabolism in vivo and in vitro but also the homeostasis of drug-exposed microbial communities may be disturbed.
Xiaolei Cheng, Haihong Zheng, Chunmei Wang, Xiaoyang Wang, Chenzhong Fei, Wen Zhou, Keyu Zhang   +6 more
doaj   +1 more source

Natural and experimental salinomycin poisoning associated with the use of florfenicol in pigs [PDF]

Pesquisa Veterinária Brasileira, 2022
: This study describes the spontaneous and experimental salinomycin poisoning associated with the use of florfenicol and warns about the effects of the administration of antibiotics to animals that receive ionophores in the feed as growth promoters.
Amanda Q. Carvalho, Cláudia S. Wisser, Guilherme O. Manfioletti, Natalia Rigo, José Cristani, Sandra D. Traverso   +5 more
doaj   +1 more source

The comparative assessment of single dose versus co-administration of salinomycin and MK-2206 on viability, apoptosis, and gene expression of human prostate cancer cells

Journal of Current Biomedical Reports, 2023
Globally, the most prevalent medical condition affecting males is identified as prostate cancer (PCa). The aim of the present study was the comparative assessment of single dose versus co-administration of salinomycin and MK-2206 on several laboratory ...
Mohamadreza Savaee, Ali Bakhshi, Mehran Dehghanian, Ghafour Yarahmadi, Fatemeh Yaghoubi, Fatemeh Pourrajab   +5 more
doaj   +1 more source

The Effect of the Supplementation of Humic Substances and Fermented Products in the Feed on the Content of Salinomycin Residues in Poultry Tissues

Foods, 2023
The presence of antimicrobial residues in products of animal origin is a constant problem for consumer health. The aim of this study was to observe the effect of the addition of humic substances (H), fermented products (F) and a mixture of both (FH) to ...
Simona Hriciková, Ivona Kožárová, Beáta Koréneková, Slavomír Marcinčák   +3 more
doaj   +1 more source

Growth, hematological and histopathological responses to guar (cyamopsis tetragonoloba) and salinomycin sodium for ameliorating deleterious effects of coccidiosis in broiler chicken [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2021
Coccidiosis is a preeminent threat to productivity in broiler industry. This prospective study was undertaken to evaluate the anti-coccidial efficacy of guar (Cyamopsis tetragonoloba) and Salinomycin Sodium in broiler Chicken.
Omer NASEER, Jawaria Ali KHAN, Muhammad SHAHID, Ameer Hamza RABBANI, Abdullah Saghir AHMAD, Muhammad Luqman SOHAIL, Junaid NASEER, Muhammad BILAL, Waqas ABBAS, Muhammad Usman SALEEM, Yasir Razzaq KHAN, Ahmad ALI, Kashif HUSSAIN   +12 more
doaj   +1 more source

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.

PLoS ONE, 2019
ObjectivesSalinomycin is a polyether antibiotic with selective activity against human cancer stem cells. The impact of salinomycin on patient-derived primary human colorectal cancer cells has not been investigated so far.
Johannes Klose, Stefan Trefz, Tobias Wagner, Luca Steffen, Arsalie Preißendörfer Charrier, Praveen Radhakrishnan, Claudia Volz, Thomas Schmidt, Alexis Ulrich, Sebastian M Dieter, Claudia Ball, Hanno Glimm, Martin Schneider   +12 more
doaj   +1 more source

Assessment of the application for modification of the terms of the authorisation of the feed additive consisting of <i>Bacillus velezensis</i>ATCC PTA-6737 (PB6) for all pigs, all poultry species for fattening or reared for laying/breeding, laying hens, minor poultry species for laying and ornamental birds (Kemin Europa N.V.). [PDF]

EFSA J
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the preparation consisting of viable spores of Bacillus velezensis ATCC PTA‐6737 (tradename PB6). PB6 is currently authorised for use as a zootechnical additive (functional group: gut flora stabilisers) for all poultry
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Theodoridou K, Anguita M, Innocenti ML, Galobart J, Brozzi R.   +19 more
europepmc   +2 more sources

Acute Salinomycin Toxicosis of Pigs [PDF]

Journal of Veterinary Diagnostic Investigation, 1995
Salinomycin is a monovalent carboxylic ionophore that forms lipid-soluble complexes primarily with potassium ions. It was approved as a coccidiostat for chickens by the Federal Drug Administration in 1983. Overdosage or use in nontarget animal species can result in toxicosis. A case of salinomycin toxicosis in pigs is reported here.
K H, Plumlee, B, Johnson, F D, Galey
openaire   +2 more sources

Salinomycin Triggers Human Colorectal Cancer HCT116 Cell Death by Targeting Unfolded Protein Responses and Autophagy Pathways [PDF]

Iranian Journal of Colorectal Research, 2023
Background: Autophagy and the unfolded protein response (UPR) are important pathways in colorectal tumorigenesis and drug resistance, rendering them as potential therapeutic targets for treating this cancer.
Mozhdeh Zamani, Morvarid Siri, Sanaz Dastghaib, Pooneh Mokarram   +3 more
doaj   +1 more source

Primary Human Hepatocytes, But not HepG2 or Balb/c 3T3 Cells, Efficiently Metabolize Salinomycin and Are Resistant to Its Cytotoxicity

Molecules, 2020
Salinomycin is a polyether antibiotic showing anticancer activity. There are many reports of its toxicity to animals but little is known about the potential adverse effects in humans. The action of the drug may be connected to its metabolism. That is why
Lidia Radko, Małgorzata Olejnik, Andrzej Posyniak   +2 more
doaj   +1 more source