Results 11 to 20 of about 5,454 (214)

Salinomycin: A new paradigm in cancer therapy [PDF]

Tumor Biology, 2017
The primary hurdle in the treatment of cancer is acquisition of resistance by the tumor cells toward multiple drugs and selectively targeting the cancer stem cells.
Jayant Dewangan, Sonal Srivastava, Srikanta Kumar Rath   +2 more
doaj   +4 more sources

Dichloroacetate and Salinomycin as Therapeutic Agents in Cancer

Medical Sciences
Cancer is the second leading cause of mortality worldwide. Despite the available treatment options, a majority of cancer patients develop drug resistance, indicating the need for alternative approaches.
Sunny Hunt, Anita Thyagarajan, Ravi P. Sahu   +2 more
doaj   +4 more sources

Monitoring of autophagy is complicated—salinomycin as an example [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015
Monitoring of autophagy is challenging because of its multiple steps and lack of single befitting technique for a complete mechanistic understanding, which makes the task complicated. Here, we evaluate the functionality of autophagy triggered by salinomycin (anti-cancer stem cell agent) using flow cytometry and advanced microscopy.
Jangamreddy, Jaganmohan Reddy, Panigrahi, Soumya, Łos, Marek J.   +2 more
openaire   +3 more sources

Retrospective Study of Salinomycin Toxicosis in 66 Cats [PDF]

Veterinary Medicine International, 2010
We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes.
Pakozdy, Akos, Challande-Kathman, Iris, Doherr, Marcus, Cizinauskas, Sigitas, Wheeler, Simon J., Oevermann, Anna, Jaggy, Andre   +6 more
openaire   +7 more sources

Impact of salinomycin on the intestinal microflora of broiler chickens [PDF]

Acta Veterinaria Scandinavica, 2007
Background The ionophoric coccidiostat salinomycin is widely used in chicken feed. In the near future the use of ionophore coccidiostats may be banned as has been the case for other antimicrobial growth promoters.
Pedersen Karl, Bjerrum Lotte, Johansen Charlotte H   +2 more
doaj   +2 more sources

Assessment of the application for modification of the terms of authorisation of the feed additive consisting of Heyndrickxia faecalis DSM 32016 (TechnoSpore50®) (Biochem Zusatzstoffe Handels‐ und Produktionsges. mbH) [PDF]

EFSA Journal, Volume 24, Issue 10, October 2026.
Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the modification of the terms of authorisation of Heyndrickxia faecalis (formerly identified as Weizmannia faecalis) DSM 32016 (TechnoSpore50®), as a zootechnical feed additive authorised for use in all poultry species for fattening, reared for ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Giovanna Martelli, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Katerina Theodoridou, Montserrat Anguita, Rosella Brozzi, Matteo L. Innocenti, Jaume Galobart, Alberto Navarro Villa, Sofia Sandalli   +22 more
wiley   +2 more sources

Multi‐Targeting Non‐Specific Genome Engineering in Bacteria [PDF]

Advanced Science, Volume 13, Issue 25, 4 May 2026.
In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun, Ruixiang You, Yiwen Zhou, Huiyan He, Wenfang Wang, Xudong Qu, Yinhua Lu, Lei Li   +7 more
wiley   +2 more sources

Chloroquine inhibits salinomycin-induced autophagy for collaborative anticancer effect in breast cancer [PDF]

BioImpacts
Introduction: Breast cancer (BC) presents significant morbidity and mortality challenges. Autophagy plays a contradictory role in BC. The chemotherapeutic agent salinomycin exhibits anticancer effects, but its effectiveness is limited by over-activation ...
Xiaoting Yang, Zhan Jin, Gao Chen, Gaobo Hu   +3 more
doaj   +2 more sources

PATHOLOGICAL AND SERUM BIOCHEMICAL EFFECTS OF SALINOMYCIN ON LAYER CHICKS [PDF]

Pakistan Veterinary Journal, 2008
Effects of continuous and over dosage of salinomycin was studied experimentally in layer chicks.Salinomycin was given to layers @ 60, 120 and 180 ppm in feed up to the age of 12 weeks.
F. RIZVI, A. D. ANJUM, A. KHAN, M. MOHSAN AND M. SHAZAD
doaj   +2 more sources

High-Resolution Electrospray and Ion Mobility Sequential Mass Spectrometry for Structural Characterisation of Anticancer Stem Cell Agent Salinomycin and Its Isomers [PDF]

Molecules
Salinomycin is a polyether ionophore natural product widely studied for its anticancer stem cell properties and well established anti-coccidial activity.
Candy Jiang, Paul J. Gates
doaj   +2 more sources