Results 31 to 40 of about 3,796 (173)
Molecular Cancer, 2019 Background Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct death-related reason in UM patients.
Jingfeng Zhou +7 more
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Progress and application of salinomycin-induced cell autophagy in anti-cancer treatment
浙江大学学报. 农业与生命科学版, 2016 Autophagy is a cell self-eating process that allows the orderly degradation and recycling of misfolded proteins and damaged organelles through lysosome.
CHEN Siyuan, HU Ji'an
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Salinomycin-loaded Nanofibers for Glioblastoma Therapy [PDF]
Scientific Reports, 2018 AbstractSalinomycin is an antibiotic that has recently been introduced as a novel and effective anti-cancer drug. In this study, PLGA nanofibers (NFs) containing salinomycin (Sali) were fabricated by electrospinning for the first time. The biodegradable PLGA NFs had stability for approximately 30 days and exhibited a sustained release of the drug for ...
Mohammad Norouzi +3 more
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Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis [PDF]
Angewandte Chemie, 2015 AbstractTetrahydropyran rings are a common feature of complex polyketide natural products, but much remains to be learned about the enzymology of their formation. The enzyme SalBIII from the salinomycin biosynthetic pathway resembles other polyether epoxide hydrolases/cyclases of the MonB family, but SalBIII plays no role in the conventional cascade of
Luhavaya, Hanna +5 more
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Evaluation of ionophore resistance in field isolates of Eimeria tenella from Jammu and Kashmir
Indian Journal of Animal Sciences, 2023 The present study was conducted to evaluate resistance against ionophores (salinomycin and maduramicin) in four field isolates (F) of Eimeria tenella collected from four distantly located poultry farms from Union territory of Jammu and Kashmir.
AIMAN KHURSHEED +9 more
doaj +1 more source
VIEW, EarlyView.Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf +5 more
wiley +1 more source
Brazilian Journal of Medical and Biological Research, 2017 Chemotherapy response rates in patients with cholangiocarcinoma remain low, primarily due to the development of drug resistance. Epithelial-mesenchymal transition (EMT) of cancer cells is widely accepted to be important for metastasis and progression ...
Z. Yu +7 more
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Antibiotics, 2022 The anti-coccidiosis agent salinomycin is a polyether antibiotic produced by Streptomyces albus BK3-25 with a remarkable titer of 18 g/L at flask scale, suggesting a highly efficient export system.
Xian Liu +5 more
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BRD9 inhibition as potential treatment option for testicular germ cell tumors
Andrology, EarlyView.Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen +5 more
wiley +1 more source
Monitoring of autophagy is complicated—salinomycin as an example
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2015 Monitoring of autophagy is challenging because of its multiple steps and lack of single befitting technique for a complete mechanistic understanding, which makes the task complicated. Here, we evaluate the functionality of autophagy triggered by salinomycin (anti-cancer stem cell agent) using flow cytometry and advanced microscopy.
Jangamreddy, Jaganmohan Reddy +2 more
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