Assessment of the application for modification of the terms of the authorisation of the feed additive consisting of <i>Bacillus velezensis</i>ATCC PTA-6737 (PB6) for all pigs, all poultry species for fattening or reared for laying/breeding, laying hens, minor poultry species for laying and ornamental birds (Kemin Europa N.V.). [PDF]
EFSA JAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the preparation consisting of viable spores of Bacillus velezensis ATCC PTA‐6737 (tradename PB6). PB6 is currently authorised for use as a zootechnical additive (functional group: gut flora stabilisers) for all poultry
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) +19 more
europepmc +2 more sources
Novel Cerium(IV) Coordination Compounds of Monensin and Salinomycin
Molecules, 2023 The largely uncharted complexation chemistry of the veterinary polyether ionophores, monensic and salinomycinic acids (HL) with metal ions of type M4+ and the known antiproliferative potential of antibiotics has provoked our interest in exploring the ...
Nikolay Petkov +7 more
semanticscholar +1 more source
Acute Salinomycin Toxicosis of Pigs [PDF]
Journal of Veterinary Diagnostic Investigation, 1995 Salinomycin is a monovalent carboxylic ionophore that forms lipid-soluble complexes primarily with potassium ions. It was approved as a coccidiostat for chickens by the Federal Drug Administration in 1983. Overdosage or use in nontarget animal species can result in toxicosis. A case of salinomycin toxicosis in pigs is reported here.
K H, Plumlee, B, Johnson, F D, Galey
openaire +2 more sources
Salinomycin as a potential chemotherapeutic compound in cisplatin-resistant ovarian cancer : effects and mechanisms [PDF]
, 2013 Ovarian cancer is the most frequent cause of death from gynecological cancer. Even though there are a lot of options in treating gynecological malignancies, the therapeutic effect of ovarian cancer nowadays is still unfavourable, especially in treatment ...
Bei, Zhang
core +1 more source
Salinomycin Triggers Human Colorectal Cancer HCT116 Cell Death by Targeting Unfolded Protein Responses and Autophagy Pathways [PDF]
Iranian Journal of Colorectal Research, 2023 Background: Autophagy and the unfolded protein response (UPR) are important pathways in colorectal tumorigenesis and drug resistance, rendering them as potential therapeutic targets for treating this cancer.
Mozhdeh Zamani +3 more
doaj +1 more source
Salinomycin as a potent anticancer stem cell agent: State of the art and future directions
Medicinal research reviews (Print), 2021 Cancer stem cells (CSCs) are a small subpopulation of cells within a tumor that can both self‐renew and differentiate into other cell types forming the heterogeneous tumor bulk.
Dan Qi +5 more
semanticscholar +1 more source
Veterinary World, 2022 Background and Aim: Salinomycin sodium, a licensed coccidiostat in rabbits, is used for fattening at a dose of 20–25 mg/kg. Salinomycin toxicity may arise from many risk factors (e.g., overdosage or use in non-target animal species).
Ahmed. H. Ghonaim +6 more
semanticscholar +1 more source
Matrifibrocytes Redefine Cardiac Fibrosis: From Terminal Differentiation to Translational Modulation. [PDF]
J Cell Mol MedABSTRACT Cardiac fibrosis is increasingly recognized as a dynamic program that resolves into a terminal fibroblast fate, the matrifibrocyte, rather than a persistent myofibroblast state. Lineage‐tracing and single‐cell studies reveal that matrifibrocytes arise from activated myofibroblasts during late scar maturation, lose α‐SMA and proliferative ...
Zhang Z, Zhu H.
europepmc +2 more sources
International Journal of Medical Sciences, 2021 Salinomycin (Sal) is a recently identified anti-tumor drug for treating several types of solid tumor; however, its effects on the migratory and invasive properties of non-small cell lung cancer (NSCLC) remain unclear.
K. Hwang +8 more
semanticscholar +1 more source
Salinomycin Toxicity in Turkeys
Poultry Science, 1986 Five 7-day trials using 336, 24, 24, 40, and 40 Large White male turkeys when 7, 11, 15, 27, and 32 weeks of age, respectively, were conducted to determine the toxic effects of salinomycin. Salinomycin became more toxic as the age of the turkeys increased.
L M, Potter +4 more
openaire +2 more sources