Results 51 to 60 of about 7,383 (256)

Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells

Drug Delivery, 2021
Intra-tumor heterogeneity is widely accepted as one of the key factors, which hinders cancer patients from achieving full recovery. Especially, cancer stem cells (CSCs) may exhibit self-renewal capacity, which makes it harder for complete elimination of ...
Qin Wang, Y. Yen, Chen Xie, Fangcen Liu, Qin Liu, Jia Wei, Lixia Yu, Lifeng Wang, F. Meng, Rutian Li, Baorui Liu   +10 more
semanticscholar   +1 more source

Early effects of the antineoplastic agent salinomycin on mitochondrial function [PDF]

, 2015
Salinomycin, isolated from Streptomyces albus, displays antimicrobial activity. Recently, a large-scale screening approach identified salinomycin and nigericin as selective apoptosis inducers of cancer stem cells.
ZORATTI, MARIO, Quintana Cabrera, R, Gulbins, E, Toninello, A, LEANZA, LUIGI, MANAGO', ANTONELLA, QUINTANA-CABRERA, RUBEN, Sassi, N, Semenzato, G, ZORATTI, Anna Maria, SASSI, NICOLA, Managò, A, GRANCARA, SILVIA, Trentin, L, Carraretto, L, SCORRANO, LUCA, TONINELLO, ANTONIO, Szabò, I., SZABO', ILDIKO', Leanza, L, CARRARETTO, LUCA, Trimarco, V, Scorrano, L, TRENTIN, LIVIO, TRIMARCO, VALENTINA   +24 more
core   +1 more source

Progress and application of salinomycin-induced cell autophagy in anti-cancer treatment

浙江大学学报. 农业与生命科学版, 2016
Autophagy is a cell self-eating process that allows the orderly degradation and recycling of misfolded proteins and damaged organelles through lysosome.
CHEN Siyuan, HU Ji'an
doaj   +1 more source

Salinomycin, a potent inhibitor of XOD and URAT1, ameliorates hyperuricemic nephropathy by activating NRF2, modulating the gut microbiota, and promoting SCFA production.

Chemico-Biological Interactions
Long-term hyperuricemia can induce kidney damage, clinically referred to as hyperuricemic nephropathy (HN), which is characterized by renal fibrosis, inflammation, and oxidative stress.
Yongjun Chen, Zitao Guo, Hai-Qiao Chen, Shifan Zhang, Y. Bao, Zhoufan Xie, Jiale Ke, Wenjie Ye, Jiacheng Liang, Jiacun Chen, Ning Li, Fengxin Zheng, Hui Liao, Ting Wu, Jianxin Pang   +14 more
semanticscholar   +1 more source

Targeting Telomerase Enhances Cytotoxicity of Salinomycin in Cancer Cells

ACS Omega, 2022
Salinomycin exhibits significant systemic adverse reactions such as tachycardia and myoglobinuria in mammals, which hinders its application as a drug for human cancers.
Hongshuang Qin, Yanxiang Guo
semanticscholar   +1 more source

Salinomycin-loaded Nanofibers for Glioblastoma Therapy [PDF]

Scientific Reports, 2018
AbstractSalinomycin is an antibiotic that has recently been introduced as a novel and effective anti-cancer drug. In this study, PLGA nanofibers (NFs) containing salinomycin (Sali) were fabricated by electrospinning for the first time. The biodegradable PLGA NFs had stability for approximately 30 days and exhibited a sustained release of the drug for ...
Mohammad Norouzi, Zahra Abdali, Song Liu, Donald W. Miller   +3 more
openaire   +2 more sources

Induction of autophagy by salinomycin.

, 2012
(A) Electron microscopic images of MCF-7 cells 48 hours after treatment with 10 µM salinomycin or solvent control. Note the vacuoles formed in the cytoplasm (arrow).
Inge Schmitz (134566), Alireza Mirmohammadsadegh (134571), Andrea Tannapfel (17108), Markus Vogt (134564), Berlinda Verdoodt (134562), Sven-Thorsten Liffers (134568)   +5 more
core   +1 more source

Anticancer activity of salinomycin quaternary phosphonium salts.

European journal of medicinal chemistry
In recent years salinomycin has emerged as a promising anticancer drug. Many literature reports have proved its remarkable antiproliferative activity. Moreover, chemical modifications of salinomycin lead to analogues with even higher cytotoxicity against
Marta Jędrzejczyk, Michał Sulik, Magdalena Mielczarek-Puta, G. Lim, Małgorzata Podsiad, Jakub Hoser, P. Bednarczyk, M. Struga, Adam Huczyński   +8 more
semanticscholar   +1 more source

Salinomycin-Loaded High-Density Lipoprotein Exerts Promising Anti-Ovarian Cancer Effects by Inhibiting Epithelial–Mesenchymal Transition

International Journal of Nanomedicine, 2022
Background Effective treatments for ovarian cancer remain elusive, and survival rates have long been considered grim. Ovarian cancer stem cells (OCSCs) and epithelial–mesenchymal transition (EMT) are associated with cancer progression and metastasis, as ...
Miao Zou, Xirui Yin, Xuan Zhou, Xinhui Niu, Yi Wang, Man-man Su   +5 more
semanticscholar   +1 more source

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis [PDF]

Angewandte Chemie, 2015
AbstractTetrahydropyran rings are a common feature of complex polyketide natural products, but much remains to be learned about the enzymology of their formation. The enzyme SalBIII from the salinomycin biosynthetic pathway resembles other polyether epoxide hydrolases/cyclases of the MonB family, but SalBIII plays no role in the conventional cascade of
Luhavaya, Hanna, Dias, Marcio VB, Williams, Simon R, Hong, Hui, de Oliveira, Luciana G, Leadlay, Peter F   +5 more
openaire   +7 more sources