Results 71 to 80 of about 5,454 (214)

A New Insight Into Salinomycin

Iranian Journal of Veterinary Medicine
Salinomycin is a polyether ionophore antibiotic used as a coccidiostat and growth promoter in veterinary medicine and animal husbandry since the 1980s. It is a promising anticancer drug that targets human cancer stem cells and inhibits tumor cell growth. It can induce autophagy, mitophagy, and mitochondrial polarity in cancer cells.
Razieh Hosseini, Ali Hajimohammadi, Negar Panahi, Hamid Rajaian   +3 more
openaire   +1 more source

Partial protection against salinomycin toxicity through inhibition of autophagy.

, 2012
Cell death was measured in SW620 by flow cytometry using the ViaCount reagent 24 hours after treatment with 10 µM salinomycin, or solvent control. (A) Cells were transfected with siRNA against ATG7, or control oligos, and treated with salinomycin 72 ...
Inge Schmitz (134566), Alireza Mirmohammadsadegh (134571), Andrea Tannapfel (17108), Markus Vogt (134564), Berlinda Verdoodt (134562), Sven-Thorsten Liffers (134568)   +5 more
core   +1 more source

Effect of salinomycin on performance of grazing stocker heifers [PDF]

, 1986
The effect of feeding 0, 25, 50, 100, or 150 mg of salinomycin per head daily on performance of stocker heifers grazing smooth bromegrass pasture was evaluated in a 126-day trial.
Lomas, Lyle W., Lyle W. Lomas
core   +1 more source

Inhibition of autophagic flux by salinomycin results in anti-cancer effect in hepatocellular carcinoma cells.

PLoS ONE, 2014
Salinomycin raised hope to be effective in anti-cancer therapies due to its capability to overcome apoptosis-resistance in several types of cancer cells.
Johannes Klose, Metodi V Stankov, Moritz Kleine, Wolf Ramackers, Diana Panayotova-Dimitrova, Mark D Jäger, Jürgen Klempnauer, Michael Winkler, Hüseyin Bektas, Georg M N Behrens, Florian W R Vondran   +10 more
doaj   +1 more source

Synthetic modification of salinomycin: selective O-acylation and biological evaluation

, 2013
Salinomycin has found renewed interest as an agent for prevention of cancer recurrence through selectively targeting cancer stem cells. Strategies for generation of improved salinomycin analogs by individual modification of its hydroxyl groups are ...
Borgström, Björn, Hegardt, Cecilia, Posta, Martin, Huang, Xiaoli, Oredsson, Stina, Strand, Daniel   +5 more
core   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells

BMC Cancer, 2019
Background Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer.
Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao, Yi Wang   +8 more
doaj   +1 more source

Polymer–lipid hybrid anti-HER2 nanoparticles for targeted salinomycin delivery to HER2-positive breast cancer stem cells and cancer cells

, 2017
Jun Li,1,* Wenqing Xu,2,* Xiaoli Yuan,3,* Huaiwen Chen,3 Hao Song,1,4 Bingquan Wang,5 Jun Han5 1College of Pharmacy, Liaocheng University, Liaocheng, Shandong, 2Railway Police College, Zhengzhou, 3Department of Cadre Health Care, Nanjing General ...
Xu WQ, Yuan XL, Li J, Chen HW, Han J, Song H, Wang BQ   +6 more
core  

Salinomycin suppresses STAT3 activation.

, 2015
(A) Basal levels of STAT3 and phospho-STAT3 (Tyr705) in seven breast cancer cell lines: luminal-type (MCF7 and T47D), HER2-amplified (BT474, MDA-MB-453, and SKBR3), and TNBC (Hs578T and MDA-MB-231).
Ji Young Kim (171004), Hyunsook An (821121), Youngkwan Cho (821124), Eunhye Oh (821122), Jae Hong Seo (821125), Nahyun Lee (821123)   +5 more
core   +1 more source

Combination of salinomycin and azd3463 reveals synergistic effect on reducing the viability of t98g glioblastoma cells

, 2020
Background: Salinomycin, an ionophore antibiotic, is known to be an effective agent in reducing the viability of Glioblastoma (GBM) cells. The combination of salinomycin with other chemotherapeutic drugs would help to overcome the drug resistance of GBM ...
Gunduz, C., Bagca, B.G., Ay, N.P.O., Asik, A., Avci, C.B., Caglar, H.O.   +5 more
core   +2 more sources