Results 91 to 100 of about 7,383 (256)

Salinomycin potentiates the cytotoxic effects of TRAIL on glioblastoma cell lines.

PLoS ONE, 2014
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been reported to exhibit therapeutic activity in cancer. However, many tumors remain resistant to treatment with TRAIL.
Alessia Calzolari, Ernestina Saulle, Maria Laura De Angelis, Luca Pasquini, Alessandra Boe, Federica Pelacchi, Lucia Ricci-Vitiani, Marta Baiocchi, Ugo Testa   +8 more
doaj   +1 more source

Copper(II), a Peculiar Metal Ion for Complexation With Monensin A Ionophore

Chemistry – A European Journal, Volume 32, Issue 14, 15 April 2026.
Copper(II) forms three chiral and EPR‐active complexes with monensinate A in methanol. Beside the bis [CuL2] and mono [CuL]+ species, the new dinuclear construct [Cu2L]3+ exhibits an [ML]+‐type and a metal salt‐type copper(II) centers weakly bound to each other through counter ion(s) and thus, being magnetically independent.
Máté Levente Kis, Bálint Hajdu, Tamás Jakusch, Zoltán Kele, Petar Dorkov, Rositsa Kukeva, Ivayla Pantcheva, Béla Gyurcsik   +7 more
wiley   +1 more source

A New Insight Into Salinomycin

Iranian Journal of Veterinary Medicine
Salinomycin is a polyether ionophore antibiotic used as a coccidiostat and growth promoter in veterinary medicine and animal husbandry since the 1980s. It is a promising anticancer drug that targets human cancer stem cells and inhibits tumor cell growth. It can induce autophagy, mitophagy, and mitochondrial polarity in cancer cells.
Razieh Hosseini, Ali Hajimohammadi, Negar Panahi, Hamid Rajaian   +3 more
openaire   +1 more source

Systematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization

Advanced Science, Volume 13, Issue 20, 9 April 2026.
ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.
Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia   +9 more
wiley   +1 more source

Partial protection against salinomycin toxicity through inhibition of autophagy.

, 2012
Cell death was measured in SW620 by flow cytometry using the ViaCount reagent 24 hours after treatment with 10 µM salinomycin, or solvent control. (A) Cells were transfected with siRNA against ATG7, or control oligos, and treated with salinomycin 72 ...
Inge Schmitz (134566), Alireza Mirmohammadsadegh (134571), Andrea Tannapfel (17108), Markus Vogt (134564), Berlinda Verdoodt (134562), Sven-Thorsten Liffers (134568)   +5 more
core   +1 more source

Inhibition of autophagic flux by salinomycin results in anti-cancer effect in hepatocellular carcinoma cells.

PLoS ONE, 2014
Salinomycin raised hope to be effective in anti-cancer therapies due to its capability to overcome apoptosis-resistance in several types of cancer cells.
Johannes Klose, Metodi V Stankov, Moritz Kleine, Wolf Ramackers, Diana Panayotova-Dimitrova, Mark D Jäger, Jürgen Klempnauer, Michael Winkler, Hüseyin Bektas, Georg M N Behrens, Florian W R Vondran   +10 more
doaj   +1 more source

Heterocyclic‐Fused Squaramides: Anionophores With Antimicrobial Activity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
Supramolecular medicinal chemistry has allowed for the development of novel drugs for the treatment of cystic fibrosis, and in the fight against cancer. However, little has been done to develop these as antimicrobial agents. Here, we describe the development of novel chemical tools to further develop supramolecular methods to combat the global plight ...
Luke Edward Brennan, Chris Samuel Hawes, Kevin Kavanagh, Robert Brian Peter Elmes   +3 more
wiley   +1 more source

Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells

BMC Cancer, 2019
Background Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer.
Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao, Yi Wang   +8 more
doaj   +1 more source

EVALUATION OF THE PROTECTIVE EFFICACY OF ANTICOCCIDIAL DRUGS AND VACCINE IN PREVENTION OF COCCIDIOSIS IN BATTEZ0041SWRY REARED CHICKENS [PDF]

Veterinary Medical Journal - Giza, 2011
Efficacy of feed additive anticoccidial drugs (Salinomycin 60 ppm or diclazuril 200 g/ton) and live vaccine "Coccivac ®)" in prevention of experimental coccidiosis in battery reared reared chickens was conducted. Clinical signs and/or mortalities, weekly
Amer M, Kutkat Abd EL-A, Manal Ali, Kh El-Bayomi, Zenab AminGirh, Elmarakby I   +5 more
doaj   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source