Results 81 to 90 of about 7,383 (256)
Natural Products as Modulators of ABC Transporters in Breast Cancer
Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan +2 more
wiley +1 more source
Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin
Circulation Research, 2021 Supplemental Digital Content is available in the text. Rationale: Cardiomyopathy is characterized by the deposition of extracellular matrix by activated resident cardiac fibroblasts called myofibroblasts.
Ryan M. Burke +11 more
semanticscholar +1 more source
Ist Salinomycin ein Radiosensitizer für Plattenepithelkarzinomzellen in vitro?
, 2017 Einleitung: Eine Bestrahlung ist bei vielen HNO-Tumorentitäten Bestandteil der Therapieregime. Aktuell wird simultan zur Bestrahlung vor allem Cisplatin aufgrund seiner radiosensibilisierenden Eigenschaften eingesetzt.
Kleinsasser, N +3 more
core +1 more source
International Journal of Molecular Sciences, 2022 Lead (Pb) exposure induces severe nephrotoxic effects in humans and animals. Herein, we compare the effects of two chelating agents, salinomycin and deferiprone, on Pb-induced renal alterations in mice and in the homeostasis of essential elements.
Y. Gluhcheva +10 more
semanticscholar +1 more source
Frontiers in Chemistry, 2021 Malignant cancer is a devastating disease often associated with a poor clinical prognosis. For decades, modern drug discoveries have attempted to identify potential modulators that can impede tumor growth.
Yongmei Zhao +5 more
semanticscholar +1 more source
PLoS ONE, 2013 A major challenge for oncologists and pharmacologists is to develop more potent and less toxic drugs that will decrease the tumor growth and improve the survival of lung cancer patients.
Kholoud Arafat +6 more
doaj +1 more source
Experimental and Therapeutic Medicine, 2021 Salinomycin is a polyether antiprotozoal antibiotic that is widely used as an animal food additive. Some antifungal, antiparasitic, antiviral and anti-inflammatory activities have been reported for salinomycin.
Jianyong Yu +3 more
semanticscholar +1 more source
British Journal of Haematology, Volume 208, Issue 5, Page 1572-1583, May 2026.Chemotherapy‐induced WNT ligand secretion by bone marrow (BM) stroma drives acute lymphoblastic leukaemia (ALL) chemoresistance. WNT pathway inhibition disrupts this cross‐talk and restores therapeutic response, highlighting WNT inhibitors as a promising strategy to prevent relapse in ALL.
Foteini Kalampalika +4 more
wiley +1 more source
Activation of the JNK pathway by salinomycin.
, 2012 (A) Exposure to 2.5 µM salinomycin induced the expression and activation of JNK, as well as its target JUN in MCF-7 cells. (B) Increased JNK kinase activity after salinomycin treatment in MCF-7. The JNK kinase assay was carried out after treatment with 2.
Inge Schmitz (134566) +5 more
core +1 more source
Influence of Salinomycin on the Performance of Broiler Chicks
Poultry Science, 1987 Two experiments were conducted to determine the influence of graded levels of salinomycin on the performance of broiler chicks. Cobb feather-sexed chicks were fed experimental diets from 1 to 21 days of age. A significant depression in body weight and feed consumption was obtained when the feed contained 77 ppm of salinomycin.
R H, Harms, R E, Buresh
openaire +2 more sources