Results 41 to 50 of about 3,796 (173)

Salinomycin Promotes Anoikis and Decreases the CD44+/CD24- Stem-Like Population via Inhibition of STAT3 Activation in MDA-MB-231 Cells.

PLoS ONE, 2015
Triple-negative breast cancer (TNBC) is an aggressive tumor subtype with an enriched CD44+/CD24- stem-like population. Salinomycin is an antibiotic that has been shown to target cancer stem cells (CSC); however, the mechanisms of action involved have not
Hyunsook An, Ji Young Kim, Eunhye Oh, Nahyun Lee, Youngkwan Cho, Jae Hong Seo   +5 more
doaj   +1 more source

Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin

BMC Veterinary Research, 2019
Background Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpose of our study was to determine if
Lucia Borlle, Abdo Dergham, Zacharie Wund, Brittany Zumbo, Teresa Southard, Kelly R. Hume   +5 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Advances in large DNA fragment assembly for microbial cell factory engineering

Quantitative Biology, Volume 14, Issue 3, September 2026.
Abstract The efficient, rapid, and reliable assembly of DNA fragments is essential for advancing metabolic engineering and synthetic biology. With the rapid advancement of DNA synthesis and assembly technologies, the scale of DNA assembly has expanded from single genes to metabolic pathways and even genomes.
Yu Zhang, Wenqian Liu, Dongyuan Cheng, Jiazhang Lian, Xian Fu, Yue Shen   +5 more
wiley   +1 more source

Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications

Frontiers in Oncology, 2021
Breast cancer (BC) is the most frequent cancer among women worldwide and is the leading cause of cancer-related deaths in women. Cancer cells with stem cell-like features and tumor-initiating potential contribute to drug resistance, tumor recurrence, and
Hui Wang, Hongyi Zhang, Yihao Zhu, Zhonghang Wu, Zhonghang Wu, Chunhong Cui, Chunhong Cui, Fengfeng Cai   +7 more
doaj   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Effect of a mixture of monoglycerides with salinomycin on the growth performance and intestine morphology in broiler chickens [PDF]

BIO Web of Conferences
This study aims to interact with the combined influence of monoglyceride supplementation and salinomycin on growth performance and the morphology of the small intestine in broiler chickens.
Siriphong Hutsanai, Prasongsook Sombat, Rakangthong Choawit, Rangubhet K.Teepalak, Poeikhampha Theerawit   +4 more
doaj   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Retrospective Study of Salinomycin Toxicosis in 66 Cats [PDF]

Veterinary Medicine International, 2010
We examined 66 cats with salinomycin intoxication. Salinomycin caused different LMN signs of varying degrees of severity in all cases. Changes in blood work were unspecific, with the most frequent being increased serum creatine kinase activity, leukocytosis, and increased liver enzymes.
Pakozdy, Akos, Challande-Kathman, Iris, Doherr, Marcus, Cizinauskas, Sigitas, Wheeler, Simon J., Oevermann, Anna, Jaggy, Andre   +6 more
openaire   +4 more sources

Impact of salinomycin on the intestinal microflora of broiler chickens

Acta Veterinaria Scandinavica, 2007
Background The ionophoric coccidiostat salinomycin is widely used in chicken feed. In the near future the use of ionophore coccidiostats may be banned as has been the case for other antimicrobial growth promoters.
Pedersen Karl, Bjerrum Lotte, Johansen Charlotte H   +2 more
doaj   +1 more source