Results 41 to 50 of about 7,383 (256)

Primary Human Hepatocytes, But not HepG2 or Balb/c 3T3 Cells, Efficiently Metabolize Salinomycin and Are Resistant to Its Cytotoxicity

Molecules, 2020
Salinomycin is a polyether antibiotic showing anticancer activity. There are many reports of its toxicity to animals but little is known about the potential adverse effects in humans. The action of the drug may be connected to its metabolism. That is why
Lidia Radko, Małgorzata Olejnik, Andrzej Posyniak   +2 more
doaj   +1 more source

Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt

BMC Cancer, 2012
Background Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal.
Kuo Selena Z, Blair Katherine J, Rahimy Elham, Kiang Alan, Abhold Eric, Fan Jian-Bing, Wang-Rodriguez Jessica, Altuna Xabier, Ongkeko Weg M   +8 more
doaj   +1 more source

Effect of live Eimeria vaccination or salinomycin on growth and immune status in broiler chickens receiving in-feed inclusion of gelatin and vitamin E

Poultry Science, 2022
This experiment determined if 2% of gelatin, to improve the levels of proline and glycine in the diet, and 70 mg/kg of vitamin E supplementation would relieve the impaired performance of male Cobb broilers vaccinated for coccidiosis.
C. Orso, B.L. Cony, J.P. Silva, Jennifer Furtado, M. Mann, J. Frazzon, A. Frazzon, I. Andretta, A. Ribeiro   +8 more
semanticscholar   +1 more source

Salinomycin induces autophagy in colon and breast cancer cells with concomitant generation of reactive oxygen species.

PLoS ONE, 2012
BackgroundSalinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance.
Berlinda Verdoodt, Markus Vogt, Inge Schmitz, Sven-Thorsten Liffers, Andrea Tannapfel, Alireza Mirmohammadsadegh   +5 more
doaj   +1 more source

Efficacy of probiotics on health status and growth performance of eimeria tenella infected broiler chickens [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2018
A probiotic containing Pediococcus acidilactici and Bacillus subtilis (Smart ProLive) at a 1x107 CFU/mL dose in drinking water were given continuously from the d 14 to the end of the treatment (d 35) in broiler chickens.
S. Zerrin ERDOĞMUŞ, Nurhayat GÜLMEZ, Ayfer FINDIK, Hüseyin ŞAH, Murat GÜLMEZ   +4 more
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In vitro evaluation of salinomycin addition in wheat straw based total mixed diets on rumen fermentation, methanogenesis and dry matter degradability in buffalo

Veterinary World, 2012
Aim: The aim of the current study was to evaluate the effect of salinomycin in vitro on methanogenesis and rumen fermentation. Materials and Methods: Different levels of (0,10, 15 and 20 ppm) salinomycin were checked for their effect on in vitro ...
Sunil K. Sirohi, Navneet Goel
doaj   +1 more source

Effect of salinomycin on EMT and stemness pathways in 5-FU-resistant breast cancer

Advances in Cancer Biology - Metastasis, 2021
Cancer stem cells (CSCs) present in tumours are the primary cause of cancer recurrence and mediates resistance against therapeutic intervention. CSC properties like epithelial-to-mesenchymal transition (EMT) and cancer stemness lead to metastasis ...
Divya Sivanesan, Raj Pranap Arun, Rama Shanker Verma   +2 more
doaj   +1 more source

Salinomycin activates AMP-activated protein kinase-dependent autophagy in cultured osteoblastoma cells: a negative regulator against cell apoptosis.

PLoS ONE, 2013
BackgroundThe malignant osteoblastoma has poor prognosis, thus the search for novel and more efficient chemo-agents against this disease is urgent.
Lun-qing Zhu, Yun-fang Zhen, Ya Zhang, Zhi-xiong Guo, Jin Dai, Xiao-dong Wang   +5 more
doaj   +1 more source

Salinomycin effectively eliminates cancer stem-like cells and obviates hepatic metastasis in uveal melanoma

Molecular Cancer, 2019
Background Uveal melanoma (UM) is the most common primary intraocular tumor. Hepatic metastasis is the major and direct death-related reason in UM patients.
Jingfeng Zhou, Shenglan Liu, Yun Wang, Wei Dai, Hailin Zou, Shubo Wang, Jing Zhang, Jingxuan Pan   +7 more
doaj   +1 more source

Salinomycin kills cancer stem cells by sequestering iron in lysosomes

Nature Chemistry, 2017
Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse ...
T. Mai, A. Hamaï, Antje Hienzsch, T. Cañeque, Sebastian Müller, Julien Wicinski, O. Cabaud, C. Leroy, A. David, Verónica Acevedo, A. Ryo, Christophe Ginestier, D. Birnbaum, E. Charafe-Jauffret, P. Codogno, M. Mehrpour, Raphaël Rodriguez   +16 more
semanticscholar   +1 more source