Results 41 to 50 of about 5,454 (214)

Effect of salinomycin on TRAIL-R2 expression.

, 2014
(A)Flow cytometric analysis of TRAIL-R2 expression of T98G and U251 cells grown for 24 h in the absence (NT) or in the presence of 10 µM salinomycin (Sal).
Lucia Ricci-Vitiani (268795), Ernestina Saulle (168702), Maria Laura De Angelis (552887), Ugo Testa (168771), Luca Pasquini (168695), Federica Pelacchi (552889), Alessia Calzolari (552886), Alessandra Boe (552888), Marta Baiocchi (552890)   +8 more
core   +1 more source

Induction of Methuosis in Breast Cancer Stem Cells by a Cobalt(III) Complex Evokes Immunotherapeutic Response

Angewandte Chemie International Edition, EarlyView.
Cancer stem cells (CSCs) drive metastasis, relapse and resist conventional apoptosis‐inducing chemotherapies. We report a cobalt(III)‐cyclam complex with pyrene and diflunisal moieties that reduces the viability of breast CSCs at low micromolar concentrations.
Jiaxin Fang, Sijie Wen, Xiao Feng, Hao Ren, Kuldip Singh, Haihua Xiao, Lingpu Zhang, Kogularamanan Suntharalingam   +7 more
wiley   +1 more source

Salinomycin-loaded Nanofibers for Glioblastoma Therapy [PDF]

Scientific Reports, 2018
AbstractSalinomycin is an antibiotic that has recently been introduced as a novel and effective anti-cancer drug. In this study, PLGA nanofibers (NFs) containing salinomycin (Sali) were fabricated by electrospinning for the first time. The biodegradable PLGA NFs had stability for approximately 30 days and exhibited a sustained release of the drug for ...
Mohammad Norouzi, Zahra Abdali, Song Liu, Donald W. Miller   +3 more
openaire   +2 more sources

Evaluation of ionophore resistance in field isolates of Eimeria tenella from Jammu and Kashmir

Indian Journal of Animal Sciences, 2023
The present study was conducted to evaluate resistance against ionophores (salinomycin and maduramicin) in four field isolates (F) of Eimeria tenella collected from four distantly located poultry farms from Union territory of Jammu and Kashmir.
AIMAN KHURSHEED, ANISH YADAV, VIKAS YADAV, OMER M SOFI, ANAND KUSHWAHA, SHAFIYA I RAFIQI, RAJESH GODARA, SHILPA SOOD, DIBYENDU CHAKRABORTY, RAJESH KATOCH   +9 more
doaj   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Salinomycin impairs HCC cell survival.

, 2014
HepG2 and Huh7 cells were exposed to increasing concentrations of Salinomycin (1, 2, 5 and 10 µM) for 24 hours. (A) Cell viability was assessed by MTS-assay; high concentrations of Salinomycin led to significantly decreased viability of both cell lines ...
Georg M. N. Behrens (562058), Hüseyin Bektas (562057), Florian W. R. Vondran (476274), Wolf Ramackers (562053), Mark D. Jäger (562055), Michael Winkler (119116), Metodi V. Stankov (562051), Moritz Kleine (562052), Johannes Klose (562050), Jürgen Klempnauer (562056), Diana Panayotova-Dimitrova (562054)   +10 more
core   +1 more source

Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin

BMC Veterinary Research, 2019
Background Cancer is a significant health threat in cats. Chemoresistance is prevalent in solid tumors. The ionophore salinomycin has anti-cancer properties and may work synergistically with chemotherapeutics. The purpose of our study was to determine if
Lucia Borlle, Abdo Dergham, Zacharie Wund, Brittany Zumbo, Teresa Southard, Kelly R. Hume   +5 more
doaj   +1 more source

Comparative Transcriptome-Based Mining of Genes Involved in the Export of Polyether Antibiotics for Titer Improvement

Antibiotics, 2022
The anti-coccidiosis agent salinomycin is a polyether antibiotic produced by Streptomyces albus BK3-25 with a remarkable titer of 18 g/L at flask scale, suggesting a highly efficient export system.
Xian Liu, Yuanting Wu, Xiaojie Zhang, Qianjin Kang, Yusi Yan, Linquan Bai   +5 more
doaj   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source

Enzymology of Pyran Ring A Formation in Salinomycin Biosynthesis [PDF]

Angewandte Chemie, 2015
AbstractTetrahydropyran rings are a common feature of complex polyketide natural products, but much remains to be learned about the enzymology of their formation. The enzyme SalBIII from the salinomycin biosynthetic pathway resembles other polyether epoxide hydrolases/cyclases of the MonB family, but SalBIII plays no role in the conventional cascade of
Luhavaya, Hanna, Dias, Marcio VB, Williams, Simon R, Hong, Hui, de Oliveira, Luciana G, Leadlay, Peter F   +5 more
openaire   +7 more sources