Results 31 to 40 of about 116,508 (264)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Laser-plasma interaction physics for shock ignition

EPJ Web of Conferences, 2013
In the shock ignition scheme, the ICF target is first compressed with a long (nanosecond) pulse before creating a convergent shock with a short (∼100 ps) pulse to ignite thermonuclear reactions.
Goyon C., Depierreux S., Michel D.T., Loisel G., Yahia V., Masson-Laborde P.E., Loiseau P., Hüller S., Borisenko N.G., Orekhov A., Rosmej O., Nicolaï P., Tikhonchuk V.T., Labaune C.   +13 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

Light: Science & Applications
Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics, plasma physics, and laser physics. Knowledge of the initial
Yasmina Azamoum, Georg Alexander Becker, Sebastian Keppler, Guillaume Duchateau, Stefan Skupin, Mickael Grech, Fabrice Catoire, Sebastian Hell, Issa Tamer, Marco Hornung, Marco Hellwing, Alexander Kessler, Franck Schorcht, Malte Christoph Kaluza   +13 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Plasma Expansion in Laser-Target Interaction Process [PDF]

مجله علوم و فنون هسته‌ای, 2012
In this paper, the behavior of temperature, density, velocity and pressure of the plasma shock front produced by the interaction of a focused Nd:YAG laser beam on a copper target, with an average pulsewidth of 30ns and 140mJ laser energy, have been ...
A.H Farahbod, M Afshari, E Agayari
doaj  

Identification of Coupling Mechanisms between Ultraintense Laser Light and Dense Plasmas

Physical Review X, 2019
The interaction of intense laser beams with plasmas created on solid targets involves a rich nonlinear physics. Because such dense plasmas are reflective for laser light, the coupling with the incident beam occurs within a thin layer at the interface ...
L. Chopineau, A. Leblanc, G. Blaclard, A. Denoeud, M. Thévenet, J-L. Vay, G. Bonnaud, Ph. Martin, H. Vincenti, F. Quéré   +9 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source