Results 41 to 50 of about 331,101 (291)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Laser-plasma interaction physics for shock ignition

EPJ Web of Conferences, 2013
In the shock ignition scheme, the ICF target is first compressed with a long (nanosecond) pulse before creating a convergent shock with a short (∼100 ps) pulse to ignite thermonuclear reactions.
Goyon C., Depierreux S., Michel D.T., Loisel G., Yahia V., Masson-Laborde P.E., Loiseau P., Hüller S., Borisenko N.G., Orekhov A., Rosmej O., Nicolaï P., Tikhonchuk V.T., Labaune C.   +13 more
doaj   +1 more source

Quasi-monoenergetic femtosecond photon sources from Thomson Scattering using laser plasma accelerators and plasma channels

, 2014
Narrow bandwidth, high energy photon sources can be generated by Thomson scattering of laser light from energetic electrons, and detailed control of the interaction is needed to produce high quality sources. We present analytic calculations of the energy-
Esarey, E., Geddes, C. G. R., Leemans, W. P., Rykovanov, S. G., Schroeder, C. B., Vay, J. -L.   +5 more
core   +1 more source

A plasma solenoid driven by an Orbital Angular Momentum laser beam [PDF]

, 2018
A tens of Tesla quasi-static axial magnetic field can be produced in the interaction of a short intense laser beam carrying an Orbital Angular Momentum with an underdense plasma.
Korneev, Ph., Nuter, R., Thiele, I., Tikhonchuk, V.   +3 more
core   +2 more sources

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

Light: Science & Applications
Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics, plasma physics, and laser physics. Knowledge of the initial
Yasmina Azamoum, Georg Alexander Becker, Sebastian Keppler, Guillaume Duchateau, Stefan Skupin, Mickael Grech, Fabrice Catoire, Sebastian Hell, Issa Tamer, Marco Hornung, Marco Hellwing, Alexander Kessler, Franck Schorcht, Malte Christoph Kaluza   +13 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Laser boron fusion reactor with picosecond petawatt block ignition

, 2017
For developing a laser boron fusion reactor driven by picosecond laser pulses of more than 30 petawatts power, advances are reported about computations for the plasma block generation by the dielectric explosion of the interaction.
Eliezer, Shalom, Hora, Heinrich, Kirchhoff, Goetz, Korn, Georg, Lalousis, Paraskevas, Miley, George H., Nissim, Noaz, Wang, Jiaxiang, Xu, Yanxia   +8 more
core   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Bright X-ray source from a laser-driven micro-plasma-waveguide

, 2015
Owing to the rapid progress in laser technology, very high-contrast femtosecond laser pulses of relativistic intensities become available. These pulses allow for interaction with micro-structured solid-density plasma without destroying the structure by ...
Pukhov, Alexander, Shen, Baifei, Thanh, Phuc Luu, Yi, Longqing   +3 more
core   +1 more source