Results 31 to 40 of about 903,118 (268)

O processo sucessório e a abertura de capital nas empresas brasileiras: objetivos conflitantes

open access: yesRAE: Revista de Administração de Empresas, 1994
A abertura de capital de uma companhia pode não ser a solução adequada a problemas de sucessão em empresas familiares brasileiras.
Jairo Laser Procianoy
doaj  

Enhancing laser beam performance by interfering intense laser beamlets

open access: yesNature Communications, 2019
Enhanced coupling of laser energy to the target particles is a fundamental issue in laser-plasma interactions. Here the authors demonstrate increased photon absorption leading into higher laser to electron and proton energy transfer through the ...
A. Morace   +26 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Implementation of Ag/ SiO2 nanofilms for metamaterial engineering

open access: yesResults in Physics, 2022
Low dimensions of the nanostructured thin films are essential in applications of miniaturized optical systems. Noble metal thin films of different thicknesses (4–10 nm) were obtained by radio frequency magnetron sputtering (rfMS) with controlled ...
Petronela Prepelita   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Low spatial frequency laser-induced periodic surface structures in fused silica inscribed by widely tunable femtosecond laser pulses

open access: yesScientific Reports, 2022
The formation and evolution of laser-induced periodic surface structures in fused silica under irradiation of widely tunable (in the 1–3  $$\upmu$$ μ m range) linearly polarized femtosecond (200 fs) pulses was studied experimentally.
Marius Navickas   +4 more
doaj   +1 more source

Argon laser angioplasty with a laser probe [PDF]

open access: yesJournal of Vascular Surgery, 1987
A preliminary basic study of argon laser angioplasty with the use of a specially designed probe is presented. Arterial specimens were harvested from 10 amputated lower extremities. The studies included the evaluation of coaxial laser angioplasty in 10 partially or totally occluded arteries; the observation of the effect of perpendicularly applied laser
Y, Yang   +5 more
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study

open access: yesInternational Journal of Hyperthermia, 2019
Objective/Purpose: In order to study the effects of hyperthermia and other temperature-related effects on cells and tissues, determining the precise time/temperature course is crucial.
Yoko Miura   +6 more
doaj   +1 more source

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