Results 51 to 60 of about 2,070,930 (266)

Enhancing laser beam performance by interfering intense laser beamlets

Nature Communications, 2019
Enhanced coupling of laser energy to the target particles is a fundamental issue in laser-plasma interactions. Here the authors demonstrate increased photon absorption leading into higher laser to electron and proton energy transfer through the ...
A. Morace, N. Iwata, Y. Sentoku, K. Mima, Y. Arikawa, A. Yogo, A. Andreev, S. Tosaki, X. Vaisseau, Y. Abe, S. Kojima, S. Sakata, M. Hata, S. Lee, K. Matsuo, N. Kamitsukasa, T. Norimatsu, J. Kawanaka, S. Tokita, N. Miyanaga, H. Shiraga, Y. Sakawa, M. Nakai, H. Nishimura, H. Azechi, S. Fujioka, R. Kodama   +26 more
doaj   +1 more source

Implementation of Ag/ SiO2 nanofilms for metamaterial engineering

Results in Physics, 2022
Low dimensions of the nanostructured thin films are essential in applications of miniaturized optical systems. Noble metal thin films of different thicknesses (4–10 nm) were obtained by radio frequency magnetron sputtering (rfMS) with controlled ...
Petronela Prepelita, Florin Garoi, Marius Dumitru, Valentin Craciun   +3 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Optical trapping with superfocused high-M2 laser diode beam [PDF]

, 2015
Many applications of high-power laser diodes demand tight focusing. This is often not possible due to the multimode nature of semiconductor laser radiation possessing beam propagation parameter M2 values in double-digits.
Kuchinskii, V. I., S. N. Loseva, Deryagin, A. G., M. Farsarib, Soboleva, K.K., V. V. Dudelev, W. Sibbett, Rafailov, E. U., Dudelev, V. V., Melissinaki, V., Deryagin, A.G., V. V. Dudeleva, Sobolev, K. K., K. K. Soboleva, V. Melissinaki, Kuchinskii, V.I., A. G. Deryagin, V. I. Kuchinskiia, Rafailov, E.U., G. S. Sokolovskii, Losev, S.N., A. G. Deryagina, V. I. Kuchinskii, M. Farsari, K. K. Sobolevac, Sokolovskii, G.S., V. Melissinakib, W. Sibbette, G. S. Sokolovskiia, Sokolovskii, G. S., Dudelev, V.V., E. U. Rafailov, Farsari, M., Losev, S. N., Sibbett, W., E. U. Rafailovf, S. N. Losev   +36 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Surface tension stabilized laser welding (donut laser welding)—A new laser welding technique

, 2013
A new laser welding process is presented which delivers a porosity free, spatter free weld. The process involves a donut shaped melt with a central hole of the same order of magnitude as the material thickness.
Kaplan, Alexander,, John Powell, Powell, John,, Alexander Kaplan, Ingemar Eriksson, Eriksson, Ingemar,, Haglund, Peter,, Peter Haglund   +7 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source