Results 41 to 50 of about 5,089,608 (342)

Longitudinal Laser Shaping in Laser Wakefield Accelerators [PDF]

, 2000
We study the energetics of wake excitation during the laser-plasma interaction in application to laser wakefield accelerators. We find that both the wake amplitude and the accelerating efficiency (transformer ratio) can be maximized by properly shaping ...
Anatoly Spitkovsky, Bane, Chen, Chen, Chen, Chen, Esarey, Esarey, Esarey, Mori, Pisin Chen, Spitkovsky, Sprangle, Tajima, Verluise, Wilks   +15 more
core   +2 more sources

Appraising the holistic value of Lenvatinib for radio-iodine refractory differentiated thyroid cancer: A multi-country study applying pragmatic MCDA

BMC Cancer, 2017
Background The objective of the study was to reveal through pragmatic MCDA (EVIDEM) the contribution of a broad range of criteria to the value of the orphan drug lenvatinib for radioiodine refractory differentiated thyroid cancer (RR-DTC) in country ...
Monika Wagner, Hanane Khoury, Liga Bennetts, Patrizia Berto, Jenifer Ehreth, Xavier Badia, Mireille Goetghebeur   +6 more
doaj   +1 more source

Rod Laser – The first laser was a rod laser [PDF]

Laser Technik Journal, 2005
Laser technology is relatively young. The first laser was built in 1960 by Maiman at AT&T Labs in the USA. It was a rod-shaped ruby laser, this arrangement having been chosen for its favourable symmetry (Fig. 1). Starting from this device, the technology of solid-state lasers developed rapidly.
Hans Amler, Josef Thumbs
openaire   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Petawatt Laser Guiding and Electron Beam Acceleration to 8 GeV in a Laser-Heated Capillary Discharge Waveguide.

Physical Review Letters, 2019
Guiding of relativistically intense laser pulses with peak power of 0.85 PW over 15 diffraction lengths was demonstrated by increasing the focusing strength of a capillary discharge waveguide using laser inverse bremsstrahlung heating.
A. Gonsalves, Kei Nakamura, J. Daniels, C. Benedetti, C. Pieronek, C. Pieronek, T. D. Raadt, S. Steinke, J. Bin, S. Bulanov, J. V. Tilborg, C. Geddes, C. Schroeder, C. Schroeder, C. Tóth, E. Esarey, K. Swanson, K. Swanson, L. Fan-Chiang, L. Fan-Chiang, G. Bagdasarov, G. Bagdasarov, N. Bobrova, V. Gasilov, V. Gasilov, G. Korn, P. Sasorov, W. Leemans, W. Leemans   +28 more
semanticscholar   +1 more source

An overview of laser surface modification of die steels [PDF]

, 2008
In recent years, surface modification using advanced heat source like laser has been replacing the conventional methods to produce amorphous microstructure via rapid solidification.
Aqida, S.N., Brabazon, Dermot, Maurel, M., Naher, Sumsun   +3 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Impact of Postoperative Intravenous Iron Therapy on Clinical Outcomes in Surgical Patients with Iron-Deficiency Anemia: A Comparative Analysis by Frailty Status in the Setting of Elective Cardiac Surgery

Medicina
Background and Objectives: This study aimed to comparatively investigate the impact of postoperative intravenous iron therapy (IVIT) as an add-on to preoperative IVIT on clinical outcomes in frail versus non-frail patients with iron-deficiency anemia ...
Laser Şanal, Erdal Şimşek, Serdar Günaydın   +2 more
doaj   +1 more source