Results 31 to 40 of about 1,205,027 (295)

Table-top optical parametric chirped pulse amplifiers: past and present

open access: yesOpto-Electronic Advances, 2023
The generation of power- and wavelength-scalable few optical cycle pulses remains one of the major challenges in modern laser physics. Over the past decade, the development of table-top optical parametric chirped pulse amplification-based systems was ...
Audrius Dubietis, Aidas Matijošius
doaj   +1 more source

Analysis of hybrid Nd:Yag laser-MAG arc welding processes. [PDF]

open access: yes, 2011
In the hybrid laser-arc welding process, a laser beam and an electric arc are coupled in order to combine the advantages of both processes: high welding speed, low thermal load and high depth penetration thanks to the laser; less demanding on joint ...
F. Coste   +9 more
core   +1 more source

Tapered amplifier laser with frequency-shifted feedback

open access: yesSciPost Physics, 2016
We present a frequency-shifted feedback (FSF) laser based on a tapered amplifier. The laser operates as a coherent broadband source with up to 370GHz spectral width and 2.3us coherence time.
A. Bayerle, S. Tzanova, P. Vlaar, B. Pasquiou, F. Schreck
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Simulation of laser-driven cratering experiments on aluminum [PDF]

open access: yes, 2019
After a brief description of the physical principles involved in the cratering process, the authors present a specific methodology to simulate laser-driven cratering experiments performed with a long pulse duration (100 ns) and a small focal spot ...
Jean-Luc Rullier   +11 more
core   +1 more source

Few-cycle Yb-doped laser sources for attosecond science and strong-field physics

open access: yesAPL Photonics
Yb-doped laser amplifiers have, in recent years, found applications in attosecond science, driven largely by the opportunities associated with high-average-power and high-repetition-rate attosecond sources.
Tran-Chau Truong   +4 more
doaj   +1 more source

Compact Aberration-Free Relay-Imaging Multi-Pass Layouts for High-Energy Laser Amplifiers

open access: yesApplied Sciences, 2016
We present the results from a theoretical investigation of laser beam propagation in relay imaging multi-pass layouts, which recently found application in high-energy laser amplifiers.
Jörg Körner   +2 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

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