Results 31 to 40 of about 479 (218)

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

Photonics
Chirped pulse amplification (CPA) has been a commonly used methodology to obtain powerful ultrashort laser pulses ever since its first demonstration. However, wavelength-tunable CPA systems are much less common.
Xinyang Liu, Regina Gumenyuk
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Self-injection-locked thin-film regenerative laser amplifier

iScience
Summary: Organic lasers based on distributed feedback (DFB) microcavities have been extensively investigated. However, the application of these lasers is limited by their low output power and large beam divergence.
Yue Liu, Wenwen Wu, Xinping Zhang
doaj   +1 more source

High-Power, Wavelength-Locked 878.6 nm In-Band Pumped, Acoustic-Optically Q-Switched Nd:YVO₄ MOPA Laser With TEM₀₀ Mode

IEEE Photonics Journal, 2016
In this paper, a wavelength-locked 878.6-nm pumped acoustic-optically Q-switched Nd:YVO4 laser is presented. A master oscillator power amplifier configuration with two-stage amplifiers is employed to scale the output power.
Qiang Liu, Mingming Nie, Fuyuan Lu, Mali Gong   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Control of the formation and amplification of pulse bursts in regenerative amplifiers

IET Control Theory & Applications, 2023
This paper presents control strategies to generate bursts of high‐intensity laser pulses with arbitrary envelope from regenerative amplifiers by suitably adjusting the energy of the injected seed pulses. To this end, existing and experimentally validated
Andreas Deutschmann‐Olek, Katharina Schrom, Andreas Kugi   +2 more
doaj   +1 more source

Polarization-maintaining large-mode-area solid-core anti-resonant fiber for high-power fiber lasers

Results in Physics, 2023
A polarization-maintaining large-mode-area solid-core anti-resonant fiber is investigated in this work with double-layer anti-resonant elements for improved capability on fundamental mode guidance and higher order mode suppression, and structural and ...
Hao Tian, Shijie Fu, Quan Sheng, Haichen Xu, Shuai Zhang, Wei Shi, Jianquan Yao   +6 more
doaj   +1 more source