Results 41 to 50 of about 12,641 (308)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber

Photonics
Chirped pulse amplification (CPA) has been a commonly used methodology to obtain powerful ultrashort laser pulses ever since its first demonstration. However, wavelength-tunable CPA systems are much less common.
Xinyang Liu, Regina Gumenyuk
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Self-injection-locked thin-film regenerative laser amplifier

iScience
Summary: Organic lasers based on distributed feedback (DFB) microcavities have been extensively investigated. However, the application of these lasers is limited by their low output power and large beam divergence.
Yue Liu, Wenwen Wu, Xinping Zhang
doaj   +1 more source

High-Power, Wavelength-Locked 878.6 nm In-Band Pumped, Acoustic-Optically Q-Switched Nd:YVO₄ MOPA Laser With TEM₀₀ Mode

IEEE Photonics Journal, 2016
In this paper, a wavelength-locked 878.6-nm pumped acoustic-optically Q-switched Nd:YVO4 laser is presented. A master oscillator power amplifier configuration with two-stage amplifiers is employed to scale the output power.
Qiang Liu, Mingming Nie, Fuyuan Lu, Mali Gong   +3 more
doaj   +1 more source

Optimisation of short pulse multi-stage Yb fiber amplifier systems using commercial gain-modelling software

, 2006
We demonstrate the accuracy of commercial telecommunications industry software for modelling Yb-fiber amplifiers. Simulations enabled optimisation of a broad bandwidth ultra-short pulse four-stage amplifier system. The predicted results were confirmed by
D. J. Richardson, Richardson, David J., F. He, J.H.V. Price, He, Fei, Price, Jonathan H.V.   +5 more
core   +1 more source

Numerical analysis of pulse pedestal and dynamic chirp formation on picosecond modelocked laser pulses after propagation through a semiconductor optical amplifier [PDF]

, 2005
A numerical analysis, based on a modified Schrodinger equation, of the formation of pulse pedestals and dynamic chirp formation on picosecond pulses after propagation through a semiconductor optical amplifier is presented.
Anandarajah, Prince M., Barry, Liam P., M.J. Connellya, Clarke, Aisling M., P.M. Anandarajah, L.P. Barry, A.M. Clarke, Connelly, Michael J.   +7 more
core   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source