Results 41 to 50 of about 1,205,027 (295)
Wavelength-Tunable Chirped Pulse Amplification System (1720 nm–1800 nm) Based on Thulium-Doped Fiber
PhotonicsChirped pulse amplification (CPA) has been a commonly used methodology to obtain powerful ultrashort laser pulses ever since its first demonstration. However, wavelength-tunable CPA systems are much less common.
Xinyang Liu, Regina Gumenyuk
doaj +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Self-injection-locked thin-film regenerative laser amplifier
iScienceSummary: Organic lasers based on distributed feedback (DFB) microcavities have been extensively investigated. However, the application of these lasers is limited by their low output power and large beam divergence.
Yue Liu, Wenwen Wu, Xinping Zhang
doaj +1 more source
IEEE Photonics Journal, 2016 In this paper, a wavelength-locked 878.6-nm pumped acoustic-optically Q-switched Nd:YVO4 laser is presented. A master oscillator power amplifier configuration with two-stage amplifiers is employed to scale the output power.
Qiang Liu +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Fibre laser sources with low quantum defect
, 2014 High power fibre lasers with efficient amplification of optical signals have been widely used for various applications for many years. A great advantage of fibres is their thermal properties, which are so good that fibres are often quoted as being immune
Yao, Tianfu
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Cladding-pumped Raman fibre laser sources
, 2011 In this thesis, I investigate cladding-pumped Raman fibre lasers and amplifiers. Such devices, offering a novel way to generate Raman gain, combine the advantages of the hugely successful cladding-pumped rare-earth doped fibre lasers with those of ...
Ji, Junhua
core +2 more sources
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source