Results 41 to 50 of about 479 (218)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Exploring the Impact of Inlet Velocity Distribution on the Thermal Performance of a Laser Rod in a Diode Side-Pumped Amplifier

Photonics
Research on the thermal analysis of laser diode (LD) side-pumped amplifiers is a critical step in the design of high-power solid-state laser systems.
Shuzhen Nie, Jinglan Lin, Tianzhuo Zhao, Xiaolong Liu   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A 20 W, Less-Than-1-kHz Linewidth Linearly Polarized All-Fiber Laser

Applied Sciences, 2018
We report a continuous-wave high-output power and narrow-linewidth all-fiber laser at 1550 nm with the master oscillator power amplifier (MOPA) configuration. An all-fiber distributed feedback seed laser was boosted by three cascaded fiber amplifiers. In
Mingyuan Xue, Cunxiao Gao, Linquan Niu, Shaolan Zhu, Chuandong Sun, Jian Zhang, Haodong He   +6 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

1.5-dimensional simulation of free electron maser amplifiers

Physical Review Special Topics. Accelerators and Beams, 2005
A 1.5-dimensional model of Compton/Raman free-electron laser (FEL) amplifiers with helical wigglers has been composed by using the helical-trajectory approach.
A. V. Elzhov, A. K. Kaminsky, E. A. Perelstein, S. N. Sedykh, A. P. Sergeev   +4 more
doaj   +1 more source

Experimental Investigations on TMI and IM-FWM in Distributed Side-Pumped Fiber Amplifier

IEEE Photonics Journal, 2020
The inter-modal four-wave mixing (IM-FWM) and transversal mode instabilities (TMI) are experimentally studied in high-power distributed side-pumped fiber amplifiers.
Heng Chen, Jianqiu Cao, Zhihe Huang, Yuan Tian, Zhiyong Pan, Xiaolin Wang, Jinbao Chen   +6 more
doaj   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

High-Repetition-Rate 2.3–2.7 µm Acousto-Optically Tuned Narrow-Line Laser System Comprising Two Master Oscillators and Power Amplifiers Based on Polycrystalline Cr²⁺:ZnSe with the 2.1 µm Ho³⁺:YAG Pulsed Pumping

Photonics
High-average-power narrow-linewidth tunable solid-state lasers in the wavelength region between 2 and 3 μm are attractive light sources for many applications.
Oleg Antipov, Ilya Eranov, Stanislav Balabanov, Anton Dobryinin, Yuri Getmanovskiy, Valeriy Sharkov, Nikolay Yudin   +6 more
doaj   +1 more source