Results 41 to 50 of about 2,558,289 (248)

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

open access: yesMolecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth   +17 more
wiley   +1 more source

Time-division-multiplexed interrogation of fibre Bragg grating sensors using laser diodes [PDF]

open access: yes, 2001
An intensity-based technique for the interrogation of fibre Bragg grating sensors is described. The technique utilizes two longitudinal modes of a single, pulsed laser diode as a dual-wavelength source for grating illumination.
Wilson, A.   +2 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

open access: yesMolecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim   +11 more
wiley   +1 more source

Temperature measurement inside and near the weld pool during laser welding [PDF]

open access: yes, 1999
The work in this article deals with the measurement of temperature fields inside and near the weld pool during laser welding. The laser source used for this study is a 7.5 kW CO2 laser, and the welded material is a UNS N08904 austenitic stainless steel ...
J. Quesada   +9 more
core   +1 more source

Touchless Mechanism to Detect Rhodamine B Concentration in Distilled Water Using Fiber Bundle

open access: yesInternational Journal of Optics, 2019
Detection of rhodamine B concentration in distilled water can be conducted without direct contact between the sensor probe and the sample using fiber bundle as a sensor probe and concave mirror as a sample container. The fiber bundle used is a concentric
Samian   +4 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

open access: yesMolecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir   +9 more
wiley   +1 more source

Rapid and accurate reverse engineering of geometry based on a multi-sensor system [PDF]

open access: yes, 2014
The reduction of the lead time in measurement and reverse engineering, and the increased requirements in terms of accuracy and flexibility, have resulted in a great deal of research effort aimed at developing and implementing multi-sensor systems.
Longstaff, Andrew P.   +8 more
core   +1 more source

An optical angle sensor based on chromatic dispersion with a mode-locked laser source

open access: yesJournal of Advanced Mechanical Design, Systems, and Manufacturing, 2018
This paper proposes a new optical angle sensor, in which a mode-locked laser is employed as the light source, and chromatic dispersion of a collimator objective is utilized to detect the angular displacement of a target of interest.
Yuki SHIMIZU   +3 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Development of Portable Gear Laser Measuring Devices

open access: yesJixie chuandong, 2023
Based on the linear laser displacement sensor, this research constructs a device which can measure the multiple deviations online of large gears. In this device, the tooth profile of the gear can be scanned by the linear laser displacement sensor, and ...
Qiu Zhou   +3 more
doaj  

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