Results 41 to 50 of about 5,055,638 (241)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Postfilament-Induced Two-Photon Fluorescence of Dyed Liquid Aerosol Enhanced by Structured Femtosecond Laser Pulse

Atmosphere
Laser-induced fluorescence spectroscopy (LIFS) is actively used for remote sensing of atmospheric aerosols and is currently one of the most sensitive and selective techniques for determining small concentrations of substances inside particles. The use of
Dmitry V. Apeksimov, Pavel A. Babushkin, Yury E. Geints, Andrey M. Kabanov, Elena E. Khoroshaeva, Victor K. Oshlakov, Alexey V. Petrov, Alexander A. Zemlyanov   +7 more
doaj   +1 more source

Measuring atmospheric naphthalene with laser-induced fluorescence [PDF]

Atmospheric Chemistry and Physics, 2004
A new method for measuring gas-phase naphthalene in the atmosphere is based on laser-induced fluorescence at low pressure. The fluorescence spectrum of naphthalene near 308 nm was identified.
M. Martinez, M. Martinez, H. Harder, H. Harder, X. Ren, R. L. Lesher, W. H. Brune   +6 more
doaj  

A Comparison of Different Methods for Fissure Caries Detection

Acta Medica Bulgarica, 2016
The aim of the study is to compare the diagnostic capabilities of three different diagnostic methods: Quantitative Laser Fluorescence (QLF) − DIAGNOdent Classic (DD), Light-Induced Fluorescence (LIF) − SoproLife daylight and blue fluorescence, and their ...
Peycheva K., Boteva E.
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Evaluation of Limiting Sensitivity of the One-Color Laser Fragmentation/Laser-Induced Fluorescence Method in Detection of Nitrobenzene and Nitrotoluene Vapors in the Atmosphere

Atmosphere, 2019
The paper presents the results of a numerical evaluation of limiting sensitivity of the method for detecting vapors of nitrocompounds in the atmosphere based on one-color laser fragmentation (LF)/laser-induced fluorescence (LIF) of NO fragments via A2 ...
Sergei Bobrovnikov, Evgeny Gorlov, Viktor Zharkov   +2 more
doaj   +1 more source

Visualization of the soot formation process in the volatile flame of single coal particle using 10-kHz PAHs-PLIF, LII and LIS

Nihon Kikai Gakkai ronbunshu, 2021
Soot formation process during coal combustion is one of a key phenomenon to achieve a high-performance furnace. This is because the thermal radiation of soot influences the temperature distribution and the heat transfer process in the furnaces.
Shinya SAWADA, Daisuke OKADA, Noriaki NAKATSUKA, Kazuki TAINAKA, Tsukasa HORI, Jun HAYASHI, Fumiteru AKAMATSU   +6 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Highly sensitive laser-induced fluorescence detector for algal identification by capillary electrophoresis

Talanta Open
To achieve rapid and efficient detection of algal cells, this study developed a high-sensitivity laser-induced fluorescence detector with dimensions of 14 × 5.7 × 2.8 cm3.
Chenyang Ding, Yuanhang Wang, Yong Zheng, Jiashan Lu, Guiqiu Wang, Xuhui Geng   +5 more
doaj   +1 more source