Results 41 to 50 of about 582,709 (287)

Pulsed Laser Photo-Crosslinking of Gelatin Methacryloyl Hydrogels for the Controlled Delivery of Chlorpromazine to Combat Antimicrobial Resistance

Pharmaceutics, 2022
Hydrogels are ideal candidates for the sustained local administration of antimicrobial drugs because they have customizable physicochemical properties that allow drug release kinetics to be controlled and potentially address the issue of systemic side ...
Tatiana Tozar, Simona Nistorescu, Mihai Boni, Gratiela Gradisteanu Pircalabioru, Irina Negut, Angela Staicu   +5 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Efficient injection of radiation-pressure-accelerated sub-relativistic protons into laser wakefield acceleration based on 10 PW lasers

, 2018
We propose a hybrid laser-driven ion acceleration scheme using a combination target of a solid foil and a density-tailored background plasma. In the first stage, a sub-relativistic proton beam can be generated by the radiation pressure acceleration in ...
Chen, M., He, M. Q., Li, Y. T., Liu, M., Sheng, Z. M., Wang, H. C., Weng, S. M., Zhang, J., Zhao, Q.   +8 more
core   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Effect of electropolishing on vacuum furnace design

Journal of Electrochemical Science and Engineering, 2015
The use of thermal shields of materials having low emissivity in vacuum furnaces is well-known. However, the surface condition of the heat shields is one of the most important factors governing their efficiency as radiation resistances. The emissivity of
Sutanwi Lahiri, Girish Kumar Sahu, Biswaranjan Dikshit, Radhelal Bhardwaj, Ashwini Dixit, Ranjna Kalra, Kiran Thakur, Kamalesh Dasgupta, Asoka Kumar Das, Lalit Mohan Gantayet   +9 more
doaj   +3 more sources

Citrate polymer optical fiber for measuring refractive index based on LSPR sensor

Scientific Reports
Fiber optic localized surface plasmon resonance (LSPR) sensors have become an effective tool in refractive index (RI) detection for biomedical applications because of their high sensitivity.
Fatemeh Arefnia, Mohammad Ismail Zibaii, Azam Layeghi, Soroush Rostami, Mohammad-Mahdi Babakhani-Fard, Fatemeh Mortazavi Moghadam   +5 more
doaj   +1 more source

Pulsed coaxial plasma jets for CO2 dissociation at Martian pressures: Magnetic confinement for modeling local supercritical conditions

Results in Physics
This study explores the use of high-density plasma jets, generated by a coaxial plasma gun, for efficient CO2 dissociation into oxygen under Martian pressure conditions (1–5 Torr).
Adrian Scurtu, Dorina Ticoș, Constantin Diplașu, Nicoleta Udrea, Maria Luiza Mitu, Beatrice Paraschiv, Cătalin M. Ticoș   +6 more
doaj   +1 more source

Ion laser plasmas [PDF]

Proceedings of the IEEE, 1971
The typical noble gas ion laser plasma consists of a high-current-density glow discharge in a noble gas, in the presence of a magnetic field. Typical CW plasma conditions are current densities of 100 to 2000 A/cm2, tube diameters of 1 to 10 mm, filling pressures of 0.1 to 1.0 torr, and an axial magnetic field of the order of 1000 G.
Bridges, William B., Chester, Arthur N., Halsted, A. Stevens, Parker, Jerald V.   +3 more
openaire   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source