Results 61 to 70 of about 322,270 (296)

Photonic crystals as functional mirrors for semiconductor lasers [PDF]

, 2008
In recent years, interest has grown in the research fields of semiconductor lasers and photonic crystals. This thesis looks at integrating photonic crystals into existing semiconductor laser technology to act as functional laser mirrors.
Moore, Stephen A.
core   +2 more sources

Spatio-temporal control of attosecond pulses by using driver with flat-top spatial profile [PDF]

EPJ Web of Conferences
XUV beams produced by high order harmonic generation in gas present order-dependent spatial characteristics, leading to spatio-temporal couplings especially near focus. Using a driver with flat-top spatial profile helps controlling spatial homogeneity of
Valentin C., Prawdziak S., Boukhaoui D., Catoire F., Fedorov N., Veyrinas K., Burgy F., Péjot C., Picot C., Constant E., Mével E.   +10 more
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Wavelength tunable lasers in future optical communication systems [PDF]

, 2008
Monolithic tunable lasers (TL) have been an important component in dense wavelength division multiplexed (DWDM) systems mainly because of their ability to reduce inventory costs associated with different part numbers for fixed wavelength distributed ...
Anandarajah, Prince M., Barry, Liam P., P. M. Anandarajah, R. Maher, Kaszubowska-Anandarajah, Aleksandra, L. P. Barry, A. Kaszubowska, Maher, Robert D.   +7 more
core   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Theoretical study of the impact of adaptation on cell-fate heterogeneity and fractional killing

Scientific Reports, 2020
Fractional killing illustrates the cell propensity to display a heterogeneous fate response over a wide range of stimuli. The interplay between the nonlinear and stochastic dynamics of biochemical networks plays a fundamental role in shaping this ...
Julien Hurbain, Darka Labavić, Quentin Thommen, Benjamin Pfeuty   +3 more
doaj   +1 more source

RF or THz signals generated from DC biased multimode lasers [PDF]

, 2007
Although self pulsating (SP) lasers are DC biased, they feature a modulation of the output power. For the results presented in this paper, the SP frequency corresponds to the frequency spacing between longitudinal modes or its second harmonic.
Frederic Surre, Surre, Frederic, Latkowski, Sylwester, Sylwester Latkowski, Pascal Landais, Landais, Pascal   +5 more
core   +2 more sources