Results 41 to 50 of about 19,763 (266)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Glacial chronology of the Sierra Nevada, California, from the Last Glacial Maximum to the Holocene

Cuadernos de Investigación Geográfica, 2017
During the Last Glacial Maximum the Sierra Nevada in California, USA, supported a mountain glacier/ice cap complex that covered over 20,000 km2. The history of this ice cover can be reconstructed using 14C and cosmogenic-nuclide surface-exposure dating ...
F. Phillips
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Differential distribution shifts in two subregions of East Asian subtropical evergreen broadleaved forests—a case of Magnoliaceae

Frontiers in Plant Science
AimEast Asian subtropical evergreen broad-leaved forests (EBLFs) are composed of western and eastern subregions with different topographical and environmental conditions.
Hai-Yang Wu, Yue-Han Liu, Qiu-Xiang He, Jun-Wei Ye, Bin Tian, Bin Tian   +5 more
doaj   +1 more source

The Pyrenees: glacial landforms prior to the Last Glacial Maximum

, 2022
Middle Pleistocene glaciation in the Pyrenees is still poorly documented, but the record of ice fluctuations that occurred before 29 ka within the time span of the Late Pleistocene has benefited from a growing catalogue of geochronological data. Here we provide an exhaustive review of results obtained from different generations of ice-marginal deposits
Delmas, Magali, Gunnell, Yanni, Calvet, Marc, Reixach, Théo, Oliva, Marc   +4 more
openaire   +3 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

High-resolution interpolar difference of atmospheric methane around the Last Glacial Maximum [PDF]

Biogeosciences, 2012
Reconstructions of past atmospheric methane concentrations are available from ice cores from both Greenland and Antarctica. The difference observed between the two polar methane concentration levels represents a valuable constraint on the geographical
M. Baumgartner, A. Schilt, O. Eicher, J. Schmitt, J. Schwander, R. Spahni, H. Fischer, T. F. Stocker   +7 more
doaj   +1 more source

Last Glacial Maximum CO2 and δ13C successfully reconciled [PDF]

Geophysical Research Letters, 2011
During the Last Glacial Maximum (LGM, ∼21,000 years ago) the cold climate was strongly tied to low atmospheric CO2 concentration (∼190 ppm). Although it is generally assumed that this low CO2 was due to an expansion of the oceanic carbon reservoir, simulating the glacial level has remained a challenge especially with the additional δ13C constraint ...
Bouttes, Nathaëlle, Paillard, D., Roche, Didier M., Brovkin, V., Bopp, L.   +4 more
openaire   +3 more sources