Results 51 to 60 of about 2,996,723 (294)

Late-onset hypogonadism (LOH) : an emerging pathophysiological entity requiring the physician's attention [PDF]

, 2006
Late-onset hypogonadism (LOH) is an emerging pathophysiological entity. Not everybody is familiar with LOH or even recognizes its existence. Since the 19th century women's life expectancy has become progressively greater than that of men and therefore ...
Nieschlag, Eberhard
core  

Swiss national guideline for reimbursement of enzyme replacement therapy in late-onset Pompe disease. [PDF]

, 2013
Glycogen storage disease type II is a rare multi-systemic disorder characterised by an intracellular accumulation of glycogen due a mutation in the acid alpha glucosidase (GAA) gene.
Hundsberger, Thomas, Rösler, Kai Michael, Rohrbach, Marianne, Kern, Lukas   +3 more
core   +2 more sources

Three-Country Snapshot of Ornithine Transcarbamylase Deficiency

Life, 2022
X-linked ornithine transcarbamylase deficiency (OTCD) is the most common urea cycle defect. The disease severity ranges from asymptomatic carrier state to severe neonatal presentation with hyperammonaemic encephalopathy.
Berna Seker Yilmaz, Julien Baruteau, Nur Arslan, Halil Ibrahim Aydin, Magalie Barth, Ayse Ergul Bozaci, Anais Brassier, Ebru Canda, Aline Cano, Efstathia Chronopoulou, Grainne M. Connolly, Lena Damaj, Charlotte Dawson, Dries Dobbelaere, Claire Douillard, Fatma Tuba Eminoglu, Sahin Erdol, Melike Ersoy, Sherry Fang, François Feillet, Gulden Gokcay, Emine Goksoy, Magali Gorce, Asli Inci, Banu Kadioglu, Fatih Kardas, Cigdem Seher Kasapkara, Gonca Kilic Yildirim, Deniz Kor, Melis Kose, Cecilia Marelli, Helen Mundy, Siobhan O’Sullivan, Burcu Ozturk Hismi, Radha Ramachandran, Agathe Roubertie, Mehtap Sanlilar, Manuel Schiff, Srividya Sreekantam, Karolina M. Stepien, Ozlem Uzun Unal, Yilmaz Yildiz, Tanyel Zubarioglu, Paul Gissen   +43 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Early – versus late-onset preeclampsia: differences in risk factors and birth outcomes

, 2017
Introduction. Preeclampsia (PE) continues to be a leading cause of maternal and fetal morbidity and mortality worldwide with an incidence of 3–5 %. Recently evidence suggests that PE can be subdivided into early-onset PE (EOP), requiring delivery before ...
Medvyedyeva O., Markin L.
core   +1 more source

Serum levels of GDF15 are reduced in preeclampsia and the reduction is more profound in late-onset than early-onset cases [PDF]

, 2016
Background: Preeclampsia is a pregnancy specific disorder affecting 3-5% of pregnancies worldwide. It is clinically divided into early-onset and late-onset subtypes. Placental factors are involved in the pathogenesis of preeclampsia.
Fabricio da Silva Costa, Min Zhao, da Silva Costa, Fabricio, Yao Wang, Chen, Qi, Zhao, Min, Jonathan Hyett, Wang, Yao, Guiying Nie, Hyett, Jon A. (R20572), Hyett, Jonathan, Nie, Guiying, Costa, Fabricio da Silva, Qi Chen   +13 more
core   +1 more source

Late onset clozapine induced agranulocytosis

Indian Journal of Psychological Medicine, 2014
Agranulocytosis is defined as an absolute neutrophil count less than 100/mm 3 in association with infectious disease. The risk of agranulocytosis is 0.38% of all clozapine treated cases and there is a relatively lesser incidence in Indian population. The
Rajmohan Velayudhan, Sushil Kakkan
doaj   +1 more source

Kawasaki Disease Complicated by Late-Onset Fatal Cerebral Infarction: A Case Report and Literature Review

Frontiers in Pediatrics, 2021
Background: Cerebral infarction is a rare neurological complication of Kawasaki disease (KD) and occurs in the acute or subacute stage. There have been no reported cases of late-onset fatal cerebral infarction presenting over 1 year after the onset of KD.
Lin Wang, Hongyu Duan, Hongyu Duan, Hongyu Duan, Hongyu Duan, Kaiyu Zhou, Kaiyu Zhou, Kaiyu Zhou, Kaiyu Zhou, Yimin Hua, Yimin Hua, Yimin Hua, Yimin Hua, Xiaoliang Liu, Xiaoliang Liu, Xiaoliang Liu, Chuan Wang, Chuan Wang, Chuan Wang, Chuan Wang   +19 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Applying machine learning techniques to the identification of late-onset hypogonadism in elderly men

, 2017
In the diagnosis of late-onset hypogonadism (LOH), the Androgen Deficiency in the Aging Male (ADAM) questionnaire or Aging Males' Symptoms (AMS) scale can be used to assess related symptoms.
Lu, Ti;Hu, Ya-Han;Tsai, Chih-Fong;Liu, Shih-Ping;Chen, Pei-Ling, 劉詩彬   +1 more
core   +1 more source