Results 141 to 150 of about 1,301,845 (266)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Balancing between A and I

Acta Oncologica
Emma Skovgaard Pedersen, Christoffer Johansen, Mette Kielsholm Thomsen   +2 more
doaj   +1 more source

Risk of genitourinary late effects after radiotherapy for prostate cancer associated with early changes in bladder shape. [PDF]

Phys Imaging Radiat Oncol
Casares-Magaz O, Raidou RG, Furmanová K, Pettersson N, Moiseenko V, Einck J, Hopper A, Knopp R, Muren LP.   +8 more
europepmc   +1 more source

Editorial: Acute toxicities and late effects of childhood cancer treatment. [PDF]

Front Pediatr, 2023
Czogała M, Muszyńska-Rosłan K.
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Professional Roles in Danish Clinics for General Late Effects After Cancer-A Qualitative Study. [PDF]

J Cancer Educ
Dieperink KB, Skøtt R, Mattsson T, Thisted LB, Christensen CØ, Tolstrup LK.   +5 more
europepmc   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Prevalence of function-limiting late effects in survivors of head and neck cancer. [PDF]

PM R
Won YH, Stubblefield MD.
europepmc   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Radiation-induced Brain Injury and the Radiation Late Effects Cohort (RLEC) of Rhesus Macaques (Macaca mulatta). [PDF]

Radiat Res
Johnson BJ, Andrews RN, Olson JD, Cline JM.   +3 more
europepmc   +1 more source